N-(3'-deoxy-β-D-thymidin-3'-yl)-N'-(4-chloro-3-trifluoromethylphenyl)-isopropylguanidine

Base Information

Chemical Name:N-(3'-deoxy-β-D-thymidin-3'-yl)-N'-(4-chloro-3-trifluoromethylphenyl)-isopropylguanidine
CAS No.:1271302-34-1
Molecular Formula:C₂₁H₂₅ClF₃N₅O₄
Molecular Weight:503.909
Hs Code.:

Synonyms:N-(3'-deoxy-β-D-thymidin-3'-yl)-N'-(4-chloro-3-trifluoromethylphenyl)-isopropylguanidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(3'-deoxy-β-D-thymidin-3'-yl)-N'-(4-chloro-3-trifluoromethylphenyl)-isopropylguanidine

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Technology Process of N-(3'-deoxy-β-D-thymidin-3'-yl)-N'-(4-chloro-3-trifluoromethylphenyl)-isopropylguanidine

There total 4 articles about N-(3'-deoxy-β-D-thymidin-3'-yl)-N'-(4-chloro-3-trifluoromethylphenyl)-isopropylguanidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 1271302-28-3
N-(3'-deoxy-5'-O-triphenylmethyl-β-D-thymidin-3'-yl)-N'-(4-chloro-3-trifluoromethylphenyl)-isopropylguanidine

: 1271302-34-1
N-(3'-deoxy-β-D-thymidin-3'-yl)-N'-(4-chloro-3-trifluoromethylphenyl)-isopropylguanidine

Guidance literature:: With formic acid; In diethyl ether; at 20 ℃; for 0.75h;
DOI:10.1039/c0ob00591f

Reference yield:

: 1219808-55-5
1-(3'-deoxy-5'-O-triphenylmethyl-β-D-thymidin-3'-yl)-3-(4-chloro-3-(trifluoromethyl)phenyl)thiourea

: 1271302-34-1
N-(3'-deoxy-β-D-thymidin-3'-yl)-N'-(4-chloro-3-trifluoromethylphenyl)-isopropylguanidine

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine; mercury dichloride / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

2: formic acid / diethyl ether / 0.75 h / 20 °C

With formic acid; triethylamine; mercury dichloride; In diethyl ether; N,N-dimethyl-formamide;
DOI:10.1039/c0ob00591f

Reference yield:

: 124355-25-5
3'-amino-3'-deoxy-5'-O-triphenylmethyl-β-D-thymidine

: 1271302-34-1
N-(3'-deoxy-β-D-thymidin-3'-yl)-N'-(4-chloro-3-trifluoromethylphenyl)-isopropylguanidine

Guidance literature:: Multi-step reaction with 3 steps

1: N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

2: triethylamine; mercury dichloride / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

3: formic acid / diethyl ether / 0.75 h / 20 °C

With formic acid; triethylamine; mercury dichloride; In diethyl ether; N,N-dimethyl-formamide;
DOI:10.1039/c0ob00591f