4-(5-Iodo-2-methoxyphenoxy)benzaldehyde

Base Information

• Chemical Name: 4-(5-Iodo-2-methoxyphenoxy)benzaldehyde
• CAS No.: 158469-55-7
• Molecular Formula: C₁₄H₁₁IO₃
• Molecular Weight: 354.144
• Mol file: 158469-55-7.mol

Synonyms:4-(5-Iodo-2-methoxyphenoxy)benzaldehyde

Chemical Property of 4-(5-Iodo-2-methoxyphenoxy)benzaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(5-Iodo-2-methoxyphenoxy)benzaldehyde

There total 5 articles about 4-(5-Iodo-2-methoxyphenoxy)benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-(2-methoxyphenoxy)benzaldehyde (78725-48-1) → 4-(5-Iodo-2-methoxyphenoxy)benzaldehyde (158469-55-7)

Guidance literature:

With Iodine monochloride; In dichloromethane; at 20 ℃; for 168h; Inert atmosphere; Darkness;

DOI:10.1002/chem.201101550

Reference yield: 99.0%

4-(5-Iodo-2-methoxyphenoxy)benzonitrile (158469-49-9) → 4-(5-Iodo-2-methoxyphenoxy)benzaldehyde (158469-55-7)

Guidance literature:

With diisobutylaluminium hydride; In diethyl ether; cyclohexane; at -78 ℃; for 7h;

DOI:10.1021/jo00097a052

Reference yield:

2-methoxy-phenol (90-05-1) → 4-(5-Iodo-2-methoxyphenoxy)benzaldehyde (158469-55-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 94 percent / K₂CO₃, CuO, pyridine / 21 h / 120 °C

2: 80 percent / H₅IO₆, I₂, aq. H₂SO₄ / acetic acid / 2 h / 90 °C

3: 99 percent / DIBAL-H / diethyl ether; cyclohexane / 7 h / -78 °C

With pyridine; sulfuric acid; iodine; diisobutylaluminium hydride; potassium carbonate; periodic acid; copper(II) oxide; In diethyl ether; cyclohexane; acetic acid;

DOI:10.1021/jo00097a052

upstream raw materials:

4-(5-Iodo-2-methoxyphenoxy)benzonitrile

4-bromobenzenecarbonitrile

4-(2'-methoxyphenoxy)benzonitrile

2-methoxy-phenol

Downstream raw materials:

Methyl (Z)-3-<4-(5-iodo-2-methoxyphenoxy)phenyl>acrylate

combretastatin D-2

3-<4-(5-Iodo-2-methoxyphenoxy)phenyl>-3-(phenylsulfanyl)propan-1-ol

Methyl 3-<4-(5-iodo-2-methoxyphenoxy)phenyl>-3-(phenylsulfanyl)propionate