4-(2-Methoxyphenoxy)benzaldehyde

Base Information

• Chemical Name: 4-(2-Methoxyphenoxy)benzaldehyde
• CAS No.: 78725-48-1
• Molecular Formula: C14H12O3
• Molecular Weight: 228.247
• European Community (EC) Number: 823-170-5
• DSSTox Substance ID: DTXSID50585635
• Nikkaji Number: J3.114.872C
• Wikidata: Q82477627
• Mol file: 78725-48-1.mol

Synonyms:4-(2-methoxyphenoxy)benzaldehyde;78725-48-1;4-(2-METHOXY-PHENOXY)-BENZALDEHYDE;SCHEMBL3969737;DTXSID50585635;AKOS000260604;CS-0236526;G40678;EN300-1716900;Z335440846

Chemical Property of 4-(2-Methoxyphenoxy)benzaldehyde

Chemical Property:

• PSA: 35.53000
• LogP: 3.30000
• XLogP3: 2.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 228.078644241
• Heavy Atom Count: 17
• Complexity: 234

Purity/Quality:

99% ^*data from raw suppliers

4-(2-Methoxyphenoxy)benzaldehyde 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=CC=C1OC2=CC=C(C=C2)C=O

Technology Process of 4-(2-Methoxyphenoxy)benzaldehyde

There total 8 articles about 4-(2-Methoxyphenoxy)benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

4-fluorobenzaldehyde (459-57-4) + 2-methoxy-phenol (90-05-1) → 4-(2-methoxyphenoxy)benzaldehyde (78725-48-1)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; Heating;

DOI:10.1002/ejoc.201601179

Reference yield: 86.0%

4-nitrobenzaldehdye (555-16-8) + 2-methoxy-phenol (90-05-1) → 4-(2-methoxyphenoxy)benzaldehyde (78725-48-1)

Guidance literature:

With [Pd((η5-C5H5)Fe[(η5-C5H3)C(Me)=N(C6H4-4-Me)])(μ-Cl)]2; caesium carbonate; In N,N-dimethyl-formamide; at 100 ℃; for 2h;

DOI:10.1002/aoc.3043

Reference yield: 72.0%

2-Methoxyphenylboronic acid (5720-06-9) + 4-nitrobenzaldehdye (555-16-8) → 4-(2-methoxyphenoxy)benzaldehyde (78725-48-1)

Guidance literature:

With C₂₉H₂₆FeN₃Pd⁽¹⁺⁾*Cl^(1-); oxygen; caesium carbonate; In 1,4-dioxane; dimethyl sulfoxide; at 100 ℃; for 24h;

DOI:10.1016/j.tet.2013.05.112

upstream raw materials:

hydrogenchloride

aluminium trichloride

hydrogen cyanide

2-methoxyphenyl phenyl ether

Downstream raw materials:

2',4-dimethoxy-4'-{2-[3-(4-formylphenoxy)-4-methoxyphenyl]ethyl}biphenyl-2-carbaldehyde

2',4-dimethoxy-4'-{2-[3-(4-hydroxymethylphenoxy)-4-methoxyphenyl]ethyl}biphenyl-2-carbaldehyde

Br^(1-)*C₄₉H₄₄O₅P⁽¹⁺⁾

2',4-dimethoxy-2-vinyl-4'-{2-[3-(4-vinylphenoxy)-4-methoxyphenyl]ethyl}biphenyl