5-{[2-(4-methoxyphenyl)-1H-benzimidazol-1-yl]methyl}-N-methyl-1,3,4-thiadiazol-2-amine

Base Information

• Chemical Name: 5-{[2-(4-methoxyphenyl)-1H-benzimidazol-1-yl]methyl}-N-methyl-1,3,4-thiadiazol-2-amine
• CAS No.: 1029062-53-0
• Molecular Formula: C₁₈H₁₇N₅OS
• Molecular Weight: 351.432

Synonyms:5-{[2-(4-methoxyphenyl)-1H-benzimidazol-1-yl]methyl}-N-methyl-1,3,4-thiadiazol-2-amine

Chemical Property of 5-{[2-(4-methoxyphenyl)-1H-benzimidazol-1-yl]methyl}-N-methyl-1,3,4-thiadiazol-2-amine

Chemical Property:

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Technology Process of 5-{[2-(4-methoxyphenyl)-1H-benzimidazol-1-yl]methyl}-N-methyl-1,3,4-thiadiazol-2-amine

There total 6 articles about 5-{[2-(4-methoxyphenyl)-1H-benzimidazol-1-yl]methyl}-N-methyl-1,3,4-thiadiazol-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

2-{[2-(4-methoxyphenyl)-1H-benzimidazol-1-yl]acetyl}-N-methylhydrazinecarbothioamide (1029062-45-0) → 5-{[2-(4-methoxyphenyl)-1H-benzimidazol-1-yl]methyl}-N-methyl-1,3,4-thiadiazol-2-amine (1029062-53-0)

Guidance literature:

With sulfuric acid; at 20 ℃; for 0.166667h;

DOI:10.1016/j.bmc.2008.02.077

Reference yield:

4-methoxy-benzaldehyde (123-11-5) → 5-{[2-(4-methoxyphenyl)-1H-benzimidazol-1-yl]methyl}-N-methyl-1,3,4-thiadiazol-2-amine (1029062-53-0)

Guidance literature:

Multi-step reaction with 5 steps

1: sodium metabisulfite

2: potassium hydroxide / dimethyl sulfoxide

3: hydrazine hydrate / ethanol

4: ethanol / 3 h / Reflux

5: sulfuric acid / 0.17 h / 20 °C / Cooling with ice

With sodium metabisulfite; sulfuric acid; hydrazine hydrate; potassium hydroxide; In ethanol; dimethyl sulfoxide;

DOI:10.1016/j.ejmech.2019.04.012

Reference yield:

1,2-diamino-benzene (95-54-5) → 5-{[2-(4-methoxyphenyl)-1H-benzimidazol-1-yl]methyl}-N-methyl-1,3,4-thiadiazol-2-amine (1029062-53-0)

Guidance literature:

Multi-step reaction with 5 steps

1: sodium metabisulfite

2: potassium hydroxide / dimethyl sulfoxide

3: hydrazine hydrate / ethanol

4: ethanol / 3 h / Reflux

5: sulfuric acid / 0.17 h / 20 °C / Cooling with ice

With sodium metabisulfite; sulfuric acid; hydrazine hydrate; potassium hydroxide; In ethanol; dimethyl sulfoxide;

DOI:10.1016/j.ejmech.2019.04.012

upstream raw materials:

2-{[2-(4-methoxyphenyl)-1H-benzimidazol-1-yl]acetyl}-N-methylhydrazinecarbothioamide

4-methoxy-benzaldehyde

1,2-diamino-benzene

2-(4-methoxyphenyl)-1H-benzimidazole

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