(ethyl-phenyl-phosphinoylmethyl)-phosphonic acid diethyl ester

Base Information

• Chemical Name: (ethyl-phenyl-phosphinoylmethyl)-phosphonic acid diethyl ester
• CAS No.: 723296-98-8
• Molecular Formula: C₁₃H₂₂O₄P₂
• Molecular Weight: 304.263
• Mol file: 723296-98-8.mol

Synonyms:(ethyl-phenyl-phosphinoylmethyl)-phosphonic acid diethyl ester

Chemical Property of (ethyl-phenyl-phosphinoylmethyl)-phosphonic acid diethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (ethyl-phenyl-phosphinoylmethyl)-phosphonic acid diethyl ester

There total 3 articles about (ethyl-phenyl-phosphinoylmethyl)-phosphonic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

Diethyl methylphosphonate (683-08-9) + ethylphenylphosphinic chloride (1499-22-5) → (ethyl-phenyl-phosphinoylmethyl)-phosphonic acid diethyl ester (723296-98-8)

Guidance literature:

Diethyl methylphosphonate; With tert.-butyl lithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.25h;

ethylphenylphosphinic chloride; In tetrahydrofuran; hexane; at -78 - -35 ℃; for 3h;

DOI:10.1039/b007868i

Reference yield:

ethylphenylphosphinic acid ethyl ester (2227-43-2) → (ethyl-phenyl-phosphinoylmethyl)-phosphonic acid diethyl ester (723296-98-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 85 percent / SOCl₂ / Heating

2.1: t-BuLi / tetrahydrofuran; hexane / 0.25 h / -78 °C

2.2: 70 percent / tetrahydrofuran; hexane / 3 h / -78 - -35 °C

With thionyl chloride; tert.-butyl lithium; In tetrahydrofuran; hexane;

DOI:10.1039/b007868i

Reference yield:

ethyl phenylphosphinate sodium salt → (ethyl-phenyl-phosphinoylmethyl)-phosphonic acid diethyl ester (723296-98-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 85 percent / SOCl₂ / Heating

2.1: t-BuLi / tetrahydrofuran; hexane / 0.25 h / -78 °C

2.2: 70 percent / tetrahydrofuran; hexane / 3 h / -78 - -35 °C

With thionyl chloride; tert.-butyl lithium; In tetrahydrofuran; hexane;

DOI:10.1039/b007868i

upstream raw materials:

Diethyl methylphosphonate

ethylphenylphosphinic chloride

ethylphenylphosphinic acid ethyl ester