1499-22-5Relevant academic research and scientific papers
Resolution of chiral phosphate, phosphonate, and phosphinate esters by an enantioselective enzyme library
Nowlan, Charity,Li, Yingchun,Hermann, Johannes C.,Evans, Timothy,Carpenter, Joseph,Ghanem, Eman,Shoichet, Brian K.,Raushel, Frank M.
, p. 15892 - 15902 (2007/10/03)
An array of 16 enantiomeric pairs of chiral phosphate, phosphonate, and phosphinate esters was used to establish the breadth of the stereoselective discrimination inherent within the bacterial phosphotriesterase and 15 mutant enzymes. For each substrate,
Practical synthesis of chiral vinylphosphine oxides by direct nucleophilic substitution. Stereodivergent synthesis of aminophosphine ligands
Oliana, Marco,King, Frank,Horton, Peter N.,Hursthouse,Hii, King Kuok
, p. 2472 - 2479 (2007/10/03)
A practical synthesis of optically pure alkylphenylvinylphosphine oxides is described, utilizing a nucleophilic displacement at phosphorus to install the vinyl moiety. The products were used to prepare classes of P-stereogenic aminophosphine (PN) and aminohydroxyphosphine (PNO) ligands. Stereocontrol can be exerted at various stages of the synthesis, to provide specific combinations of chirality in the final product. The effect of the stereogenic phosphorus and match-mismatch of chiralities of PNO ligands were examined in the asymmetric ruthenium-catalyzed hydrogen transfer reduction of three aryl ketones.
PHOSPHINIC ACID AMIDES AS MATRIX METALLOPROTEASE INHIBITORS
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, (2008/06/13)
The invention provides compounds which are useful as inhibitors of matrix metalloproteases, and which are effective in treating conditions characterized by excess activity of these enzymes. In particular, the present invention relates to a compound having
Enantiomerically pure zinc phosphonates based on mixed phosphonic acid - Phosphine oxide chiral building blocks
Fredoueil,Evain,Massiot,Bujoli-Doeuff,Bujoli
, p. 1106 - 1110 (2007/10/03)
The coordination chemistry of enantiomerically pure phosphonic acids H2O3PCH2P(O)(C6H5)(R) [R = CH3 and C2H5] with zinc is described. The structures of two new optical
Design and synthesis of phosphinamide-based hydroxamic acids as inhibitors of matrix metalloproteinases
Pikul, Stanislaw,McDow Dunham, Kelly L.,Almstead, Neil G.,De, Biswanath,Natchus, Michael G.,Anastasio, Melanie V.,McPhail, Sara J.,Snider, Catherine E.,Taiwo, Yetunde O.,Chen, Longyin,Dunaway, C. Michelle,Gu, Fei,Mieling, Glen E.
, p. 87 - 94 (2007/10/03)
A new series of hydroxamic acid-based matrix metalloproteinase (MMP) inhibitors containing a unique phosphinamide motif derived from D-amino acid was designed, synthesized, and tested for enzyme inhibition. Compounds with an R configuration at phosphorus
