(4R,5S)-3-<(2R,3R)-3-(2,5-Dimethoxy-3-nitrophenyl)-3-hydroxy-2-methylpropanoyl>-4-methyl-5-phenyl-2-oxazolidinone

Base Information

• Chemical Name: (4R,5S)-3-<(2R,3R)-3-(2,5-Dimethoxy-3-nitrophenyl)-3-hydroxy-2-methylpropanoyl>-4-methyl-5-phenyl-2-oxazolidinone
• CAS No.: 115820-52-5
• Molecular Formula: C₂₂H₂₄N₂O₈
• Molecular Weight: 444.441
• Mol file: 115820-52-5.mol

Synonyms:(4R,5S)-3-<(2R,3R)-3-(2,5-Dimethoxy-3-nitrophenyl)-3-hydroxy-2-methylpropanoyl>-4-methyl-5-phenyl-2-oxazolidinone

Chemical Property of (4R,5S)-3-<(2R,3R)-3-(2,5-Dimethoxy-3-nitrophenyl)-3-hydroxy-2-methylpropanoyl>-4-methyl-5-phenyl-2-oxazolidinone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4R,5S)-3-<(2R,3R)-3-(2,5-Dimethoxy-3-nitrophenyl)-3-hydroxy-2-methylpropanoyl>-4-methyl-5-phenyl-2-oxazolidinone

There total 5 articles about (4R,5S)-3-<(2R,3R)-3-(2,5-Dimethoxy-3-nitrophenyl)-3-hydroxy-2-methylpropanoyl>-4-methyl-5-phenyl-2-oxazolidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

2,5-dimethoxy-3-nitrobenzaldehyde (74422-90-5) + (4R,5S)-4-methyl-5-phenyl-3-propionyloxazolidin-2-one (77877-20-4) → (4R,5S)-3-<(2R,3R)-3-(2,5-Dimethoxy-3-nitrophenyl)-3-hydroxy-2-methylpropanoyl>-4-methyl-5-phenyl-2-oxazolidinone (115820-52-5)

Guidance literature:

With triethylamine; diethylboron trifluoromethanesulfonate; In dichloromethane;

DOI:10.1016/S0040-4039(00)86723-4

Reference yield:

3-nitro-5-methoxysalicylaldehyde (34549-69-4) → (4R,5S)-3-<(2R,3R)-3-(2,5-Dimethoxy-3-nitrophenyl)-3-hydroxy-2-methylpropanoyl>-4-methyl-5-phenyl-2-oxazolidinone (115820-52-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 83 percent / NaH

With sodium hydride;

DOI:10.1021/jo00054a035

Reference yield:

2-hydroxy-5-methoxybenzaldehyde (672-13-9) → (4R,5S)-3-<(2R,3R)-3-(2,5-Dimethoxy-3-nitrophenyl)-3-hydroxy-2-methylpropanoyl>-4-methyl-5-phenyl-2-oxazolidinone (115820-52-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 70 percent / 70percent HNO₃ / acetic acid / 0.75 h

2: 99 percent / K₂CO₃ / dimethylformamide / Ambient temperature

With nitric acid; potassium carbonate; In acetic acid; N,N-dimethyl-formamide;

DOI:10.1039/P19900000047

upstream raw materials:

2,5-dimethoxy-3-nitrobenzaldehyde

(4R,5S)-4-methyl-5-phenyl-3-propionyloxazolidin-2-one

3-nitro-5-methoxysalicylaldehyde

2-hydroxy-5-methoxybenzaldehyde

Downstream raw materials:

(2S,3R)-3-[3-(2,5-Dimethyl-pyrrol-1-yl)-2,5-dimethoxy-phenyl]-3-methoxy-2-methyl-propan-1-ol

(2R,3R)-3-[3-(2,5-Dimethyl-pyrrol-1-yl)-2,5-dimethoxy-phenyl]-3-methoxy-2-methyl-propionaldehyde

(2R,3R)-3-(2,5-Dimethoxy-3-nitro-phenyl)-3-methoxy-2-methyl-propionic acid methyl ester

(2R,3R)-3-[3-(2,5-Dimethyl-pyrrol-1-yl)-2,5-dimethoxy-phenyl]-3-methoxy-2-methyl-propionic acid methyl ester