(2R,3R)-3-[3-(2,5-Dimethyl-pyrrol-1-yl)-2,5-dimethoxy-phenyl]-3-methoxy-2-methyl-propionaldehyde

Base Information

Chemical Name:(2R,3R)-3-[3-(2,5-Dimethyl-pyrrol-1-yl)-2,5-dimethoxy-phenyl]-3-methoxy-2-methyl-propionaldehyde
CAS No.:122911-32-4
Molecular Formula:C₁₉H₂₅NO₄
Molecular Weight:331.412
Hs Code.:

Synonyms:(2R,3R)-3-[3-(2,5-Dimethyl-pyrrol-1-yl)-2,5-dimethoxy-phenyl]-3-methoxy-2-methyl-propionaldehyde

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Chemical Property of (2R,3R)-3-[3-(2,5-Dimethyl-pyrrol-1-yl)-2,5-dimethoxy-phenyl]-3-methoxy-2-methyl-propionaldehyde

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Technology Process of (2R,3R)-3-[3-(2,5-Dimethyl-pyrrol-1-yl)-2,5-dimethoxy-phenyl]-3-methoxy-2-methyl-propionaldehyde

There total 8 articles about (2R,3R)-3-[3-(2,5-Dimethyl-pyrrol-1-yl)-2,5-dimethoxy-phenyl]-3-methoxy-2-methyl-propionaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 122911-31-3
(2S,3R)-3-[3-(2,5-Dimethyl-pyrrol-1-yl)-2,5-dimethoxy-phenyl]-3-methoxy-2-methyl-propan-1-ol

: 122911-32-4
(2R,3R)-3-[3-(2,5-Dimethyl-pyrrol-1-yl)-2,5-dimethoxy-phenyl]-3-methoxy-2-methyl-propionaldehyde

Guidance literature:: With pyridine-SO₃ complex; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; for 0.25h; Ambient temperature;
DOI:10.1039/P19900000047

Reference yield:

: 122911-29-9
(2R,3R)-3-(2,5-Dimethoxy-3-nitro-phenyl)-3-methoxy-2-methyl-propionic acid methyl ester

: 122911-32-4
(2R,3R)-3-[3-(2,5-Dimethyl-pyrrol-1-yl)-2,5-dimethoxy-phenyl]-3-methoxy-2-methyl-propionaldehyde

Guidance literature:: Multi-step reaction with 4 steps

1: 100 percent / H₂ / 10percent Pd-C / ethanol / 2.5 h / 760 Torr

2: 91 percent / isobutyric acid / toluene / 65 h / Heating

3: 100 percent / LiAlH₄ / tetrahydrofuran / 3 h / -5 °C

4: 89 percent / SO₃*Py, Et₃N / dimethylsulfoxide; tetrahydrofuran / 0.75 h / 25 °C

With lithium aluminium tetrahydride; pyridine-SO₃ complex; hydrogen; triethylamine; isobutyric Acid; palladium on activated charcoal; In tetrahydrofuran; ethanol; dimethyl sulfoxide; toluene;

Reference yield:

: 128836-47-5
(2R,3R)-3-(2,5-Dimethoxy-3-nitro-phenyl)-3-hydroxy-2-methyl-propionic acid methyl ester

: 122911-32-4
(2R,3R)-3-[3-(2,5-Dimethyl-pyrrol-1-yl)-2,5-dimethoxy-phenyl]-3-methoxy-2-methyl-propionaldehyde

Guidance literature:: Multi-step reaction with 5 steps

1: 90 percent / NaH / tetrahydrofuran; dimethylformamide / 16 h / -5 °C

2: 100 percent / H₂ / 10percent Pd-C / ethanol / 2.5 h / 760 Torr

3: 91 percent / isobutyric acid / toluene / 65 h / Heating

4: 100 percent / LiAlH₄ / tetrahydrofuran / 3 h / -5 °C

5: 89 percent / SO₃*Py, Et₃N / dimethylsulfoxide; tetrahydrofuran / 0.75 h / 25 °C

With lithium aluminium tetrahydride; pyridine-SO₃ complex; hydrogen; sodium hydride; triethylamine; isobutyric Acid; palladium on activated charcoal; In tetrahydrofuran; ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;