Technology Process of 2α-bromo-3-oxo-5α,22α-spirosolan-12β-yl 12-benzoate
There total 11 articles about 2α-bromo-3-oxo-5α,22α-spirosolan-12β-yl 12-benzoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogenchloride; phenyltrimethylammonium tribromide;
In
tetrahydrofuran; diethyl ether;
at 0 ℃;
for 1h;
Inert atmosphere;
DOI:10.1021/ol2017033
- Guidance literature:
-
Multi-step reaction with 3 steps
1: water; potassium carbonate / methanol / 12 h / 25 °C / Inert atmosphere
2: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / dichloromethane / 0.5 h / 25 °C / Molecular sieve; Inert atmosphere
3: hydrogenchloride; phenyltrimethylammonium tribromide / tetrahydrofuran; diethyl ether / 1 h / 0 °C / Inert atmosphere
With
hydrogenchloride; tetrapropylammonium perruthennate; water; phenyltrimethylammonium tribromide; potassium carbonate; 4-methylmorpholine N-oxide;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane;
DOI:10.1021/ol2017033
- Guidance literature:
-
Multi-step reaction with 6 steps
1: sodium azide / N,N-dimethyl-formamide / 6 h / 60 °C / Inert atmosphere
2: water; triphenylphosphine / tetrahydrofuran / 18 h / 25 °C / Inert atmosphere
3: [bis(acetoxy)iodo]benzene; iodine / dichloromethane / 0.17 h / 0 °C / Inert atmosphere
4: water; potassium carbonate / methanol / 12 h / 25 °C / Inert atmosphere
5: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / dichloromethane / 0.5 h / 25 °C / Molecular sieve; Inert atmosphere
6: hydrogenchloride; phenyltrimethylammonium tribromide / tetrahydrofuran; diethyl ether / 1 h / 0 °C / Inert atmosphere
With
hydrogenchloride; sodium azide; tetrapropylammonium perruthennate; [bis(acetoxy)iodo]benzene; water; iodine; phenyltrimethylammonium tribromide; potassium carbonate; 4-methylmorpholine N-oxide; triphenylphosphine;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide;
2: Staudinger reaction / 3: Suarez oxidation;
DOI:10.1021/ol2017033
