Technology Process of 5α,22α-spirosolane-3β,12β-diyl 3-acetate 12-benzoate
There total 8 articles about 5α,22α-spirosolane-3β,12β-diyl 3-acetate 12-benzoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
[bis(acetoxy)iodo]benzene; iodine;
In
dichloromethane;
at 0 ℃;
for 0.166667h;
stereoselective reaction;
Inert atmosphere;
DOI:10.1021/ol2017033
- Guidance literature:
-
Multi-step reaction with 3 steps
1: sodium azide / N,N-dimethyl-formamide / 6 h / 60 °C / Inert atmosphere
2: water; triphenylphosphine / tetrahydrofuran / 18 h / 25 °C / Inert atmosphere
3: [bis(acetoxy)iodo]benzene; iodine / dichloromethane / 0.17 h / 0 °C / Inert atmosphere
With
sodium azide; [bis(acetoxy)iodo]benzene; water; iodine; triphenylphosphine;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
2: Staudinger reaction / 3: Suarez oxidation;
DOI:10.1021/ol2017033
- Guidance literature:
-
Multi-step reaction with 6 steps
1: pyridine; dmap / 3 h / 25 °C / Inert atmosphere
2: triethylsilane; boron trifluoride diethyl etherate / dichloromethane / 10 h / 0 °C / Inert atmosphere
3: pyridine / 2 h / 0 °C / Inert atmosphere
4: sodium azide / N,N-dimethyl-formamide / 6 h / 60 °C / Inert atmosphere
5: water; triphenylphosphine / tetrahydrofuran / 18 h / 25 °C / Inert atmosphere
6: [bis(acetoxy)iodo]benzene; iodine / dichloromethane / 0.17 h / 0 °C / Inert atmosphere
With
pyridine; triethylsilane; dmap; sodium azide; [bis(acetoxy)iodo]benzene; boron trifluoride diethyl etherate; water; iodine; triphenylphosphine;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
5: Staudinger reaction / 6: Suarez oxidation;
DOI:10.1021/ol2017033
