Technology Process of 2α-azido-3-oxo-5α,22α-spirosolan-12β-yl 12-benzoate
There total 12 articles about 2α-azido-3-oxo-5α,22α-spirosolan-12β-yl 12-benzoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
N,N,N′,N′-tetramethylguanidinium azide;
In
nitromethane;
at 0 - 25 ℃;
for 6h;
Inert atmosphere;
DOI:10.1021/ol2017033
- Guidance literature:
-
Multi-step reaction with 2 steps
1: hydrogenchloride; phenyltrimethylammonium tribromide / tetrahydrofuran; diethyl ether / 1 h / 0 °C / Inert atmosphere
2: N,N,N′,N′-tetramethylguanidinium azide / nitromethane / 6 h / 0 - 25 °C / Inert atmosphere
With
hydrogenchloride; phenyltrimethylammonium tribromide; N,N,N′,N′-tetramethylguanidinium azide;
In
tetrahydrofuran; diethyl ether; nitromethane;
DOI:10.1021/ol2017033
- Guidance literature:
-
Multi-step reaction with 5 steps
1: [bis(acetoxy)iodo]benzene; iodine / dichloromethane / 0.17 h / 0 °C / Inert atmosphere
2: water; potassium carbonate / methanol / 12 h / 25 °C / Inert atmosphere
3: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / dichloromethane / 0.5 h / 25 °C / Molecular sieve; Inert atmosphere
4: hydrogenchloride; phenyltrimethylammonium tribromide / tetrahydrofuran; diethyl ether / 1 h / 0 °C / Inert atmosphere
5: N,N,N′,N′-tetramethylguanidinium azide / nitromethane / 6 h / 0 - 25 °C / Inert atmosphere
With
hydrogenchloride; tetrapropylammonium perruthennate; [bis(acetoxy)iodo]benzene; water; iodine; phenyltrimethylammonium tribromide; potassium carbonate; 4-methylmorpholine N-oxide; N,N,N′,N′-tetramethylguanidinium azide;
In
tetrahydrofuran; methanol; diethyl ether; nitromethane; dichloromethane;
1: Suarez oxidation;
DOI:10.1021/ol2017033
