Technology Process of 3-oxo-5α,22α-spirosolan-12β-yl 12-benzoate
There total 10 articles about 3-oxo-5α,22α-spirosolan-12β-yl 12-benzoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide;
In
dichloromethane;
at 25 ℃;
for 0.5h;
Molecular sieve;
Inert atmosphere;
DOI:10.1021/ol2017033
- Guidance literature:
-
Multi-step reaction with 2 steps
1: water; potassium carbonate / methanol / 12 h / 25 °C / Inert atmosphere
2: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / dichloromethane / 0.5 h / 25 °C / Molecular sieve; Inert atmosphere
With
tetrapropylammonium perruthennate; water; potassium carbonate; 4-methylmorpholine N-oxide;
In
methanol; dichloromethane;
DOI:10.1021/ol2017033
- Guidance literature:
-
Multi-step reaction with 5 steps
1: sodium azide / N,N-dimethyl-formamide / 6 h / 60 °C / Inert atmosphere
2: water; triphenylphosphine / tetrahydrofuran / 18 h / 25 °C / Inert atmosphere
3: [bis(acetoxy)iodo]benzene; iodine / dichloromethane / 0.17 h / 0 °C / Inert atmosphere
4: water; potassium carbonate / methanol / 12 h / 25 °C / Inert atmosphere
5: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / dichloromethane / 0.5 h / 25 °C / Molecular sieve; Inert atmosphere
With
sodium azide; tetrapropylammonium perruthennate; [bis(acetoxy)iodo]benzene; water; iodine; potassium carbonate; 4-methylmorpholine N-oxide; triphenylphosphine;
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
2: Staudinger reaction / 3: Suarez oxidation;
DOI:10.1021/ol2017033
