(S)-2-amino-3-(5'-iodo-2'-methoxyphenyl)propanoic acid hydrochloride

Base Information

• Chemical Name: (S)-2-amino-3-(5'-iodo-2'-methoxyphenyl)propanoic acid hydrochloride
• CAS No.: 1095089-33-0
• Molecular Formula: C₁₀H₁₂INO₃*ClH
• Molecular Weight: 357.576
• Mol file: 1095089-33-0.mol

Synonyms:(S)-2-amino-3-(5'-iodo-2'-methoxyphenyl)propanoic acid hydrochloride

Chemical Property of (S)-2-amino-3-(5'-iodo-2'-methoxyphenyl)propanoic acid hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-amino-3-(5'-iodo-2'-methoxyphenyl)propanoic acid hydrochloride

There total 2 articles about (S)-2-amino-3-(5'-iodo-2'-methoxyphenyl)propanoic acid hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

2-methoxy-5-iodobenzyl bromide (1095089-30-7) + Ph2C=GlyOtBu → (S)-2-amino-3-(5'-iodo-2'-methoxyphenyl)propanoic acid hydrochloride (1095089-33-0)

Guidance literature:

2-methoxy-5-iodobenzyl bromide; Ph₂C=GlyOtBu; With cesium hydroxide; (2S,4S,5R)-1-(anthracen-9-ylmethyl)-5-ethenyl-2-[(R)-(prop-2-en-1-yloxy)(quinolin-4-yl)methyl]-1-azabicyclo[2.2.2]octan-1-ium bromide; In dichloromethane; at -50 ℃; for 24h; Inert atmosphere;

With hydrogenchloride; In 1,4-dioxane; dichloromethane; optical yield given as %ee; Inert atmosphere;

DOI:10.1039/b811583d

Reference yield:

2-methoxy-5-iodobenzyl bromide → (S)-2-amino-3-(5'-iodo-2'-methoxyphenyl)propanoic acid hydrochloride (1095089-33-0)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; water; at 20 ℃; for 16h; Inert atmosphere;

DOI:10.1002/asia.201000908

Reference yield: 93.0%

methanol (67-56-1) + (S)-2-amino-3-(5'-iodo-2'-methoxyphenyl)propanoic acid hydrochloride (1095089-33-0) → C11H14INO3*ClH

Guidance literature:

With thionyl chloride; for 8h; Reflux; Inert atmosphere;

DOI:10.1002/asia.201000908

upstream raw materials:

2-methoxy-5-iodobenzyl bromide

Downstream raw materials:

(S)-2-(tert-butyloxycarbonylamino)-3-(5-iodo-2-methoxyphenyl)-propionic acid

(S)-2-(benzyloxycarbonylamino)-3-(5-iodo-2-methoxyphenyl)-propionic acid

(2S,2’’’S)-2-(benzyloxcarbonylamino)-3-(4’,4’’-bis-methoxy-3’’-[tert-butyloxycarbonylamino-2’’’-methoxycarbonylethyl]-biphenyl-3’-yl)-propionic acid

C₄₉H₇₀N₆O₁₂Si