(S)-2-(benzyloxycarbonylamino)-3-(5-iodo-2-methoxyphenyl)-propionic acid

Base Information

Chemical Name:(S)-2-(benzyloxycarbonylamino)-3-(5-iodo-2-methoxyphenyl)-propionic acid
CAS No.:1095089-37-4
Molecular Formula:C₁₈H₁₈INO₅
Molecular Weight:455.249
Hs Code.:

Synonyms:(S)-2-(benzyloxycarbonylamino)-3-(5-iodo-2-methoxyphenyl)-propionic acid

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Chemical Property of (S)-2-(benzyloxycarbonylamino)-3-(5-iodo-2-methoxyphenyl)-propionic acid

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Technology Process of (S)-2-(benzyloxycarbonylamino)-3-(5-iodo-2-methoxyphenyl)-propionic acid

There total 1 articles about (S)-2-(benzyloxycarbonylamino)-3-(5-iodo-2-methoxyphenyl)-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 1095089-33-0
(S)-2-amino-3-(5'-iodo-2'-methoxyphenyl)propanoic acid hydrochloride

: 501-53-1,94274-21-2
benzyl chloroformate

: 1095089-37-4
(S)-2-(benzyloxycarbonylamino)-3-(5-iodo-2-methoxyphenyl)-propionic acid

Guidance literature:: With sodium carbonate; In 1,4-dioxane; water; for 16h; Inert atmosphere;
DOI:10.1039/b811583d

Reference yield: 74.0%

: 1095089-37-4
(S)-2-(benzyloxycarbonylamino)-3-(5-iodo-2-methoxyphenyl)-propionic acid

: 1095089-35-2
(S)-2-tert-butyloxycarbonylamino-3-[2’-methoxy-5’-(4’’,4’’,5’’,5’’-tetramethyl 1’’,3’’,2’’-dioxaborolane-2’’-yl)phenyl]-propionic acid methylester

: 1095089-39-6
(2S,2’’’S)-2-(benzyloxcarbonylamino)-3-(4’,4’’-bis-methoxy-3’’-[tert-butyloxycarbonylamino-2’’’-methoxycarbonylethyl]-biphenyl-3’-yl)-propionic acid

Guidance literature:: With palladium diacetate; caesium carbonate; tris-(o-tolyl)phosphine; In 1,4-dioxane; water; at 80 ℃; for 16h; Inert atmosphere;
DOI:10.1039/b811583d

Reference yield:

: 1095089-37-4
(S)-2-(benzyloxycarbonylamino)-3-(5-iodo-2-methoxyphenyl)-propionic acid

: 1095089-51-2
(4S,7S,10S,2’R)-10-benzyoxycarbonylamino-1¹,2¹-bis-methoxy-7-[3’-azido-2’-(tert-butyldimethyl-silyloxy)propyl]-5,8-diaza-6,9-dioxo-1,2(4,2)-dibenzenacycloundecaphane-4-methyl carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: caesium carbonate; palladium diacetate; tris-(o-tolyl)phosphine / 1,4-dioxane; water / 8 h / 80 °C / Inert atmosphere

2: benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 16 h / 0 - 20 °C / Inert atmosphere

3: 2,6-dimethylpyridine; triethylsilyl trifluoromethyl sulfonate / dichloromethane / 16 h / 20 °C / Inert atmosphere

4: N-ethyl-N,N-diisopropylamine; HATU; 1-hydroxy-7-aza-benzotriazole / dichloromethane / 38 h / 20 °C / Inert atmosphere

With 2,6-dimethylpyridine; 1-hydroxy-7-aza-benzotriazole; triethylsilyl trifluoromethyl sulfonate; palladium diacetate; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; HATU; tris-(o-tolyl)phosphine; In 1,4-dioxane; dichloromethane; water; 1: |Suzuki Coupling;
DOI:10.1002/asia.201000908