2-tert-butyl-5-{4-[2-(tert-butyldimethylsilanyloxy)-ethoxymethyl]benzyloxy}-4-chloro-3-(2H)-pyridazinone

Base Information

Chemical Name:2-tert-butyl-5-{4-[2-(tert-butyldimethylsilanyloxy)-ethoxymethyl]benzyloxy}-4-chloro-3-(2H)-pyridazinone
CAS No.:863888-30-6
Molecular Formula:C₂₄H₃₇ClN₂O₄Si
Molecular Weight:481.107
Hs Code.:

Synonyms:2-tert-butyl-5-{4-[2-(tert-butyldimethylsilanyloxy)-ethoxymethyl]benzyloxy}-4-chloro-3-(2H)-pyridazinone

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Chemical Property of 2-tert-butyl-5-{4-[2-(tert-butyldimethylsilanyloxy)-ethoxymethyl]benzyloxy}-4-chloro-3-(2H)-pyridazinone

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Technology Process of 2-tert-butyl-5-{4-[2-(tert-butyldimethylsilanyloxy)-ethoxymethyl]benzyloxy}-4-chloro-3-(2H)-pyridazinone

There total 8 articles about 2-tert-butyl-5-{4-[2-(tert-butyldimethylsilanyloxy)-ethoxymethyl]benzyloxy}-4-chloro-3-(2H)-pyridazinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 863888-29-3
{4-[2-(tert-butyldimethylsilanyloxy)ethoxymethyl]-phenyl}meyhanol

: 88093-48-5
2-tert-butyl-4-chloro-5-hydroxy-3(2H)-pyridazinone

: 863888-30-6
2-tert-butyl-5-{4-[2-(tert-butyldimethylsilanyloxy)-ethoxymethyl]benzyloxy}-4-chloro-3-(2H)-pyridazinone

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 20 ℃; for 20h;
DOI:10.1021/jm701443n

Reference yield: 84.0%

: 863888-29-3
{4-[2-(tert-butyldimethylsilanyloxy)ethoxymethyl]-phenyl}meyhanol

: 84956-71-8
2-tert-butyl-4,5-dichloro-2H-pyridazin-3-one

: 863888-30-6
2-tert-butyl-5-{4-[2-(tert-butyldimethylsilanyloxy)-ethoxymethyl]benzyloxy}-4-chloro-3-(2H)-pyridazinone

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 75 ℃; Inert atmosphere;
DOI:10.1002/cmdc.202000085

Reference yield:

: 863888-28-2
4-[2-(tert-butyldimethylsilanyloxy)ethoxymethyl]-benzoic acid methyl ester

: 863888-30-6
2-tert-butyl-5-{4-[2-(tert-butyldimethylsilanyloxy)-ethoxymethyl]benzyloxy}-4-chloro-3-(2H)-pyridazinone

Guidance literature:: Multi-step reaction with 2 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 20 °C

2: di-isopropyl azodicarboxylate / triphenylphosphine / tetrahydrofuran / 20 h / 20 °C

With lithium aluminium tetrahydride; di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran;