(S)-tert-butoxycarbonylamino[4-(7-methoxy-2-phenylquinolin-4-yloxy)phenyl]acetic acid

Base Information

• Chemical Name: (S)-tert-butoxycarbonylamino[4-(7-methoxy-2-phenylquinolin-4-yloxy)phenyl]acetic acid
• CAS No.: 928162-13-4
• Molecular Formula: C₂₉H₂₈N₂O₆
• Molecular Weight: 500.551
• Mol file: 928162-13-4.mol

Synonyms:(S)-tert-butoxycarbonylamino[4-(7-methoxy-2-phenylquinolin-4-yloxy)phenyl]acetic acid

Chemical Property of (S)-tert-butoxycarbonylamino[4-(7-methoxy-2-phenylquinolin-4-yloxy)phenyl]acetic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-tert-butoxycarbonylamino[4-(7-methoxy-2-phenylquinolin-4-yloxy)phenyl]acetic acid

There total 1 articles about (S)-tert-butoxycarbonylamino[4-(7-methoxy-2-phenylquinolin-4-yloxy)phenyl]acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

4-chloro-7-methoxy-2-phenylquinoline (189816-05-5) + N-tert-butyloxycarbonyl-L-4-hydroxyphenylglycine (69651-48-5) → (S)-tert-butoxycarbonylamino[4-(7-methoxy-2-phenylquinolin-4-yloxy)phenyl]acetic acid (928162-13-4)

Guidance literature:

With potassium tert-butylate; In dimethyl sulfoxide; at 40 ℃; for 192h;

DOI:10.1016/j.bmc.2006.11.003

Reference yield: 74.0%

ethyl (1R,2S)-1-amino-2-vinylcyclopropanecarboxylate hydrochloride (259214-54-5,259214-56-7) + (S)-tert-butoxycarbonylamino[4-(7-methoxy-2-phenylquinolin-4-yloxy)phenyl]acetic acid (928162-13-4) → C37H39N3O7 (928162-18-9)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 23h;

DOI:10.1016/j.bmc.2006.11.003

Reference yield: 73.0%

(S)-tert-butoxycarbonylamino[4-(7-methoxy-2-phenylquinolin-4-yloxy)phenyl]acetic acid (928162-13-4) + N-[(1-aminocyclopropy)carbonyl]benzenesulfonamide (625122-60-3) → C39H38N4O8S (928162-26-9)

Guidance literature:

With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; pH=10;

DOI:10.1016/j.bmc.2006.11.003

upstream raw materials:

4-chloro-7-methoxy-2-phenylquinoline

N-tert-butyloxycarbonyl-L-4-hydroxyphenylglycine

Downstream raw materials:

C₃₄H₃₅F₂N₃O₇

C₃₉H₃₈N₄O₈S

C₃₈H₄₀N₄O₈S

C₄₁H₄₀N₄O₈S