4-(3-quinolin-6-ylmethyl-3H-imidazo[4,5-b]pyridin-5-yl)-2-trifluoromethyl-benzamide

Base Information

Chemical Name:4-(3-quinolin-6-ylmethyl-3H-imidazo[4,5-b]pyridin-5-yl)-2-trifluoromethyl-benzamide
CAS No.:1459732-54-7
Molecular Formula:C₂₄H₁₆F₃N₅O
Molecular Weight:447.419
Hs Code.:

Synonyms:4-(3-quinolin-6-ylmethyl-3H-imidazo[4,5-b]pyridin-5-yl)-2-trifluoromethyl-benzamide

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Chemical Property of 4-(3-quinolin-6-ylmethyl-3H-imidazo[4,5-b]pyridin-5-yl)-2-trifluoromethyl-benzamide

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Technology Process of 4-(3-quinolin-6-ylmethyl-3H-imidazo[4,5-b]pyridin-5-yl)-2-trifluoromethyl-benzamide

There total 10 articles about 4-(3-quinolin-6-ylmethyl-3H-imidazo[4,5-b]pyridin-5-yl)-2-trifluoromethyl-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 7.0%

: 1350426-10-6
6-((5-chloro-3H-imidazo[4,5-b]pyridin-3-yl)methyl)quinoline

: 1350426-21-9
4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(trifluoromethyl)benzamide

: 1459732-54-7
4-(3-quinolin-6-ylmethyl-3H-imidazo[4,5-b]pyridin-5-yl)-2-trifluoromethyl-benzamide

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,4-dioxane; water; at 100 ℃; for 12h; Inert atmosphere;

Reference yield:

: 5382-43-4
quinoline-6-carboxamide

: 1459732-54-7
4-(3-quinolin-6-ylmethyl-3H-imidazo[4,5-b]pyridin-5-yl)-2-trifluoromethyl-benzamide

Guidance literature:: Multi-step reaction with 6 steps

1: triethylamine; trifluoroacetic anhydride / chloroform / 1.5 h / 10 °C

2: ammonia; hydrogen / methanol / 16 h / 20 °C / 760.05 Torr

3: sodium carbonate / ethanol / 12 h / 0 - 20 °C

4: tin(ll) chloride; hydrogenchloride / water / 2 h / 20 °C

5: 12 h / 100 °C

6: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,4-dioxane / 12 h / 100 °C / Inert atmosphere

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; ammonia; hydrogen; sodium carbonate; potassium carbonate; triethylamine; trifluoroacetic anhydride; tin(ll) chloride; In 1,4-dioxane; methanol; ethanol; chloroform; water;

Reference yield:

: 23395-72-4
quinoline-6-carbonitrile

: 1459732-54-7
4-(3-quinolin-6-ylmethyl-3H-imidazo[4,5-b]pyridin-5-yl)-2-trifluoromethyl-benzamide

Guidance literature:: Multi-step reaction with 5 steps

1: ammonia; hydrogen / methanol / 16 h / 20 °C / 760.05 Torr

2: sodium carbonate / ethanol / 12 h / 0 - 20 °C

3: tin(ll) chloride; hydrogenchloride / water / 2 h / 20 °C

4: 12 h / 100 °C

5: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,4-dioxane / 12 h / 100 °C / Inert atmosphere

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; ammonia; hydrogen; sodium carbonate; potassium carbonate; tin(ll) chloride; In 1,4-dioxane; methanol; ethanol; water;