Elbimilast

Base Information

Chemical Name:Elbimilast
CAS No.:418794-42-0
Molecular Formula:C₂₂H₁₄Cl₂FN₃O₃
Molecular Weight:458.276
Hs Code.:
UNII:F49V1L3QBD
DSSTox Substance ID:DTXSID20194657
Wikidata:Q27277623
NCI Thesaurus Code:C97274
Pharos Ligand ID:HD3SFLXBYHVD
ChEMBL ID:CHEMBL4568146

Synonyms:Ronomilast;Elbimilast;418794-42-0;Elbimilast [INN];Ronomilast [INN];UNII-F49V1L3QBD;F49V1L3QBD;ELB-353;ELB353;CHEMBL4568146;AWD-12353;N-(3,5-DN-ichloropyridin-4-yl)-2-(1-((4-fluorophenyl)methyl)-1H-pyrrolo(2,3-b)pyridin-3-yl)-2-oxoacetamide;N-(3,5-dichloropyridin-4-yl)-2-(1-(4-fluorobenzyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-2-oxoacetamide;N-(3,5-Dichloropyridin-4-yl)-2-[1-[(4-fluorop henyl)methyl]pyrrolo[2,3-b]pyridin-3-yl]-2-oxoacetamide;PDE4 inhibitor, elbion;PDE4 inhibitor, BioTie;D0O8JW;RONOMILAST [WHO-DD];SCHEMBL1865431;DTXSID20194657;BDBM50559692;AWD-12-353;SB14573;N-(3,5-dichloropyridin-4-yl)-2-[1-[(4-fluorophenyl)methyl]pyrrolo[2,3-b]pyridin-3-yl]-2-oxoacetamide;Q27277623;1H-PYRROLO(2,3-B)PYRIDINE-3-ACETAMIDE, N-(3,5-DICHLORO-4-PYRIDINYL)-1-((4-FLUOROPHENYL)METHYL-.ALPHA.-OXO-;N-(3,5-DICHLOROPYRIDIN-4-YL)-2-(1-((4-FLUOROPHENYL)METHYL)-1H-PYRROLO(2,3-B)PYRIDIN-3-YL)-2-OXOACETAMIDE

Suppliers and Price of Elbimilast

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of Elbimilast

Chemical Property:

XLogP3:3.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:5
Exact Mass:442.0399592
Heavy Atom Count:30
Complexity:624

Purity/Quality:: ≥98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC2=C(N=C1)N(C=C2C(=O)C(=O)NC3=C(C=NC=C3Cl)Cl)CC4=CC=C(C=C4)F
Recent ClinicalTrials:Safety and Pharmacokinetics of ELB353 in Healthy Men

Technology Process of Elbimilast

There total 4 articles about Elbimilast which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 656237-85-3
N-(3,5-dichloropyridin-4-yl) [5-benzyloxy-1-(4-fluorobenzyl)-indol-3-yl]-glyoxylic acid amide

: 418794-42-0,247584-20-9,257892-33-4
N-(3,5-dichloro-4-pyridinyl)-2-[1-(4-fluorobenzyl)-5-hydroxy-1H-indol-3-yl]-2-oxoacetamide

Guidance literature:: N-(3,5-dichloropyridin-4-yl) [5-benzyloxy-1-(4-fluorobenzyl)-indol-3-yl]-glyoxylic acid amide; With boron tribromide; In toluene; at 75 - 80 ℃; for 3h;

With water; potassium carbonate; In toluene; at 20 ℃; Product distribution / selectivity;