N-(3,5-dichloropyridin-4-yl) [5-benzyloxy-1-(4-fluorobenzyl)-indol-3-yl]-glyoxylic acid amide

Base Information

• Chemical Name: N-(3,5-dichloropyridin-4-yl) [5-benzyloxy-1-(4-fluorobenzyl)-indol-3-yl]-glyoxylic acid amide
• CAS No.: 656237-85-3
• Molecular Formula: C₂₉H₂₀Cl₂FN₃O₃
• Molecular Weight: 548.401
• Mol file: 656237-85-3.mol

Synonyms:N-(3,5-dichloropyridin-4-yl) [5-benzyloxy-1-(4-fluorobenzyl)-indol-3-yl]-glyoxylic acid amide

Chemical Property of N-(3,5-dichloropyridin-4-yl) [5-benzyloxy-1-(4-fluorobenzyl)-indol-3-yl]-glyoxylic acid amide

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(3,5-dichloropyridin-4-yl) [5-benzyloxy-1-(4-fluorobenzyl)-indol-3-yl]-glyoxylic acid amide

There total 1 articles about N-(3,5-dichloropyridin-4-yl) [5-benzyloxy-1-(4-fluorobenzyl)-indol-3-yl]-glyoxylic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,5-dichloro-4-aminopyridine (22889-78-7) + 5-benzyloxy-1-(4-fluorobenzyl)indol-3-yl-glyoxylic acid chloride (1026923-94-3) → N-(3,5-dichloropyridin-4-yl) [5-benzyloxy-1-(4-fluorobenzyl)-indol-3-yl]-glyoxylic acid amide (656237-85-3)

Guidance literature:

3,5-dichloro-4-aminopyridine; With sodium hydride; In tetrahydrofuran; at 20 ℃; for 1h;

5-benzyloxy-1-(4-fluorobenzyl)indol-3-yl-glyoxylic acid chloride; In tetrahydrofuran; at -5 - 0 ℃; for 3h; Heating / reflux;

Reference yield: 95.0%

N-(3,5-dichloropyridin-4-yl) [5-benzyloxy-1-(4-fluorobenzyl)-indol-3-yl]-glyoxylic acid amide (656237-85-3) → N-(3,5-dichloro-4-pyridinyl)-2-[1-(4-fluorobenzyl)-5-hydroxy-1H-indol-3-yl]-2-oxoacetamide (418794-42-0,247584-20-9,257892-33-4)

Guidance literature:

N-(3,5-dichloropyridin-4-yl) [5-benzyloxy-1-(4-fluorobenzyl)-indol-3-yl]-glyoxylic acid amide; With boron tribromide; In toluene; at 75 - 80 ℃; for 3h;

With water; potassium carbonate; In toluene; at 20 ℃; Product distribution / selectivity;

Reference yield: 16.1%

N-(3,5-dichloropyridin-4-yl) [5-benzyloxy-1-(4-fluorobenzyl)-indol-3-yl]-glyoxylic acid amide (656237-85-3) → N-(3,5-dichloro-1-oxopyridin-4-yl) [5-benzyloxy-1-(4-fluorobenzyl)-indol-3-yl]-glyoxylic acid amide (786688-60-6)

Guidance literature:

N-(3,5-dichloropyridin-4-yl) [5-benzyloxy-1-(4-fluorobenzyl)-indol-3-yl]-glyoxylic acid amide; With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; acetic acid; at 20 ℃; for 168h;

With potassium carbonate; In dichloromethane; water; acetic acid; for 1h; pH=8;

upstream raw materials:

3,5-dichloro-4-aminopyridine

5-benzyloxy-1-(4-fluorobenzyl)indol-3-yl-glyoxylic acid chloride

Downstream raw materials:

N-(3,5-dichloro-1-oxopyridin-4-yl) [5-benzyloxy-1-(4-fluorobenzyl)-indol-3-yl]-glyoxylic acid amide

N-(3,5-dichloro-4-pyridinyl)-2-[1-(4-fluorobenzyl)-5-hydroxy-1H-indol-3-yl]-2-oxoacetamide