(4-{2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]ethyl}cyclohexylidene)acetic acid hydrochloride

Base Information

Chemical Name:(4-{2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]ethyl}cyclohexylidene)acetic acid hydrochloride
CAS No.:1000044-56-3
Molecular Formula:C₂₁H₂₇F₃N₂O₂*ClH
Molecular Weight:432.914
Hs Code.:

Synonyms:(4-{2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]ethyl}cyclohexylidene)acetic acid hydrochloride

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Chemical Property of (4-{2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]ethyl}cyclohexylidene)acetic acid hydrochloride

Chemical Property:

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Technology Process of (4-{2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]ethyl}cyclohexylidene)acetic acid hydrochloride

There total 6 articles about (4-{2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]ethyl}cyclohexylidene)acetic acid hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: (4-{2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]ethyl}cyclohexylidene)acetic acid ethyl ester

: 1000044-56-3
(4-{2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]ethyl}cyclohexylidene)acetic acid hydrochloride

Guidance literature:: (4-{2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]ethyl}cyclohexylidene)acetic acid ethyl ester; With sodium hydroxide; water; In methanol; at 20 ℃;

With hydrogenchloride; In water; pH=1;

Reference yield:

: 76835-14-8
1-[3-(trifluoromethyl)phenyl]piperazine hydrochloride

: 1000044-56-3
(4-{2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]ethyl}cyclohexylidene)acetic acid hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / acetonitrile / Heating / reflux

2.1: hydrogenchloride / methanol; water / 20 °C

2.2: pH 10

3.1: toluene / Heating / reflux

4.1: sodium hydroxide; water / methanol / 20 °C

4.2: pH 1

With hydrogenchloride; sodium hydroxide; water; potassium carbonate; In methanol; water; toluene; acetonitrile;

Reference yield:

: 1000044-45-0
4-{2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]ethyl}cyclohexanone

: 1000044-56-3
(4-{2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]ethyl}cyclohexylidene)acetic acid hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1.1: toluene / Heating / reflux

2.1: sodium hydroxide; water / methanol / 20 °C

2.2: pH 1

With sodium hydroxide; water; In methanol; toluene;