2-(1,4-dioxaspiro[4.5]dec-8-yl)-1-[4-(3-trifluoromethylphenyl)-piperazin-1-yl]ethanone

Base Information

Chemical Name:2-(1,4-dioxaspiro[4.5]dec-8-yl)-1-[4-(3-trifluoromethylphenyl)-piperazin-1-yl]ethanone
CAS No.:1000044-42-7
Molecular Formula:C₂₁H₂₇F₃N₂O₃
Molecular Weight:412.452
Hs Code.:

Synonyms:2-(1,4-dioxaspiro[4.5]dec-8-yl)-1-[4-(3-trifluoromethylphenyl)-piperazin-1-yl]ethanone

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Chemical Property of 2-(1,4-dioxaspiro[4.5]dec-8-yl)-1-[4-(3-trifluoromethylphenyl)-piperazin-1-yl]ethanone

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Technology Process of 2-(1,4-dioxaspiro[4.5]dec-8-yl)-1-[4-(3-trifluoromethylphenyl)-piperazin-1-yl]ethanone

There total 1 articles about 2-(1,4-dioxaspiro[4.5]dec-8-yl)-1-[4-(3-trifluoromethylphenyl)-piperazin-1-yl]ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 76835-14-8
1-[3-(trifluoromethyl)phenyl]piperazine hydrochloride

: 1000044-42-7
2-(1,4-dioxaspiro[4.5]dec-8-yl)-1-[4-(3-trifluoromethylphenyl)-piperazin-1-yl]ethanone

Guidance literature:: (1,4-dioxa-spiro[4.5]-dec-8-yl)-acetic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; for 0.166667h;

1-[3-(trifluoromethyl)phenyl]piperazine hydrochloride; With triethylamine; In dichloromethane; at 20 ℃;

Reference yield: 74.0%

: 1000044-42-7
2-(1,4-dioxaspiro[4.5]dec-8-yl)-1-[4-(3-trifluoromethylphenyl)-piperazin-1-yl]ethanone

: 1000044-44-9
1-[2-(1,4-dioxaspiro[4.5]dec-8-yl)ethyl]-4-(3-trifluoromethylphenyl)piperazine

Guidance literature:: 2-(1,4-dioxaspiro[4.5]dec-8-yl)-1-[4-(3-trifluoromethylphenyl)-piperazin-1-yl]ethanone; With lithium aluminium tetrahydride; In diethyl ether; at 10 - 20 ℃;

With sodium hydroxide; In water; at 0 - 20 ℃; for 0.25h; Product distribution / selectivity;

Reference yield:

: 1000044-42-7
2-(1,4-dioxaspiro[4.5]dec-8-yl)-1-[4-(3-trifluoromethylphenyl)-piperazin-1-yl]ethanone

: (4-{2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]ethyl}cyclohexylidene)acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium aluminium tetrahydride / diethyl ether / 10 - 20 °C

1.2: 0.25 h / 0 - 20 °C

2.1: hydrogenchloride / methanol; water / 20 °C

2.2: pH 10

3.1: toluene / Heating / reflux

With hydrogenchloride; lithium aluminium tetrahydride; In methanol; diethyl ether; water; toluene;