phenyl 4-oxo-2-phenyl-3,4-dihydropyridine-1(2H)-carboxylate

Base Information

• Chemical Name: phenyl 4-oxo-2-phenyl-3,4-dihydropyridine-1(2H)-carboxylate
• CAS No.: 107971-39-1
• Molecular Formula: C₁₈H₁₅NO₃
• Molecular Weight: 293.322
• Mol file: 107971-39-1.mol

Synonyms:phenyl 4-oxo-2-phenyl-3,4-dihydropyridine-1(2H)-carboxylate

Chemical Property of phenyl 4-oxo-2-phenyl-3,4-dihydropyridine-1(2H)-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of phenyl 4-oxo-2-phenyl-3,4-dihydropyridine-1(2H)-carboxylate

There total 9 articles about phenyl 4-oxo-2-phenyl-3,4-dihydropyridine-1(2H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

phenylmagnesium bromide (100-58-3) + 1-((phenoxy)carbonyl)-4-methoxypyridinium chloride → phenyl 4-oxo-2-phenyl-3,4-dihydropyridine-1(2H)-carboxylate (107971-39-1)

Guidance literature:

With oxonium;

DOI:10.1016/S0040-4039(98)01195-2

Reference yield:

4-methoxypyridine N-oxide (1122-96-9) → phenyl 4-oxo-2-phenyl-3,4-dihydropyridine-1(2H)-carboxylate (107971-39-1)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / 5percent Pd/C / ethanol

2: 1.) THF, -23 deg C, 20 min 2.) 10percent HCl, room temperature, 10 min

With hydrogen; palladium on activated charcoal; In ethanol;

DOI:10.1016/S0040-4039(00)85000-5

Reference yield:

C19H17NO3 → phenyl 4-oxo-2-phenyl-3,4-dihydropyridine-1(2H)-carboxylate (107971-39-1)

Guidance literature:

With hydrogenchloride; water; In tetrahydrofuran; at 20 ℃; for 0.333333h; Schlenk technique; Inert atmosphere;

DOI:10.1002/anie.201303994

upstream raw materials:

phenylmagnesium bromide

phenylmagnesium chloride

4-methoxypyridine N-oxide

phenylzinc(II) bromide

Downstream raw materials:

5-Iodo-4-oxo-2-phenyl-3,4-dihydro-2H-pyridine-1-carboxylic acid phenyl ester

(RS)-2-phenyl-2,3-dihydro-1H-pyridin-4-one