methyl 5-(4-methoxyphenyl)-4-methyl-3-(4-sulfamoylphenyl)thiophene-2-carboxylate

Base Information

Chemical Name:methyl 5-(4-methoxyphenyl)-4-methyl-3-(4-sulfamoylphenyl)thiophene-2-carboxylate
CAS No.:1394374-17-4
Molecular Formula:C₂₀H₁₉NO₅S₂
Molecular Weight:417.507
Hs Code.:

Synonyms:methyl 5-(4-methoxyphenyl)-4-methyl-3-(4-sulfamoylphenyl)thiophene-2-carboxylate

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Chemical Property of methyl 5-(4-methoxyphenyl)-4-methyl-3-(4-sulfamoylphenyl)thiophene-2-carboxylate

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Technology Process of methyl 5-(4-methoxyphenyl)-4-methyl-3-(4-sulfamoylphenyl)thiophene-2-carboxylate

There total 6 articles about methyl 5-(4-methoxyphenyl)-4-methyl-3-(4-sulfamoylphenyl)thiophene-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1394374-14-1
methyl 5-bromo-4-methyl-3-(4-sulfamoylphenyl)thiophene-2-carboxylate

: 5720-07-0
4-methoxyphenylboronic acid

: 1394374-17-4
methyl 5-(4-methoxyphenyl)-4-methyl-3-(4-sulfamoylphenyl)thiophene-2-carboxylate

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In ethanol; toluene; at 25 - 100 ℃; for 1h; Inert atmosphere;

Reference yield:

: 1394374-14-1
methyl 5-bromo-4-methyl-3-(4-sulfamoylphenyl)thiophene-2-carboxylate

: 5720-07-0
4-methoxyphenylboronic acid

: 141-78-6
ethyl acetate

: 1394374-17-4
methyl 5-(4-methoxyphenyl)-4-methyl-3-(4-sulfamoylphenyl)thiophene-2-carboxylate

: C₂₁H₂₁NO₅S₂

Guidance literature:: methyl 5-bromo-4-methyl-3-(4-sulfamoylphenyl)thiophene-2-carboxylate; 4-methoxyphenylboronic acid; With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; toluene; at 25 - 100 ℃; Inert atmosphere;

ethyl acetate; In hexane;

Reference yield:

: 203195-42-0
methyl 3-bromo-4-methylthiophene-2-carboxylate

: 64-17-5
ethanol

: 5720-07-0
4-methoxyphenylboronic acid

: 613660-87-0
4-sulfamoylphenylboronic acid

: 1394374-17-4
methyl 5-(4-methoxyphenyl)-4-methyl-3-(4-sulfamoylphenyl)thiophene-2-carboxylate

: C₂₁H₂₁NO₅S₂

Guidance literature:: methyl 3-bromo-4-methylthiophene-2-carboxylate; ethanol; 4-sulfamoylphenylboronic acid; With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In toluene; at 105 ℃; for 15h; Inert atmosphere; Sealed tube;

With bromine; In dichloromethane; at 0 - 25 ℃; for 2h; Inert atmosphere;

4-methoxyphenylboronic acid; With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In ethanol; toluene; at 95 - 100 ℃; for 1h; Inert atmosphere;
DOI:10.1021/acs.jmedchem.9b01569