2,2-dimethylpropionic acid 2-[N'-(3,4-dichlorophenyl)-N''-(2,2-dimethylpropionyl)guanidino]-1-isopropyl-1H-imidazol-4-yl ester

Base Information

Chemical Name:2,2-dimethylpropionic acid 2-[N'-(3,4-dichlorophenyl)-N''-(2,2-dimethylpropionyl)guanidino]-1-isopropyl-1H-imidazol-4-yl ester
CAS No.:1310682-68-8
Molecular Formula:C₂₃H₃₁Cl₂N₅O₃
Molecular Weight:496.437
Hs Code.:

Synonyms:2,2-dimethylpropionic acid 2-[N'-(3,4-dichlorophenyl)-N''-(2,2-dimethylpropionyl)guanidino]-1-isopropyl-1H-imidazol-4-yl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2,2-dimethylpropionic acid 2-[N'-(3,4-dichlorophenyl)-N''-(2,2-dimethylpropionyl)guanidino]-1-isopropyl-1H-imidazol-4-yl ester

Chemical Property:

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Technology Process of 2,2-dimethylpropionic acid 2-[N'-(3,4-dichlorophenyl)-N''-(2,2-dimethylpropionyl)guanidino]-1-isopropyl-1H-imidazol-4-yl ester

There total 5 articles about 2,2-dimethylpropionic acid 2-[N'-(3,4-dichlorophenyl)-N''-(2,2-dimethylpropionyl)guanidino]-1-isopropyl-1H-imidazol-4-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1310682-45-1
N-(3,4-dichlorophenyl)-N'-(1-isopropyl-4-oxo-4,5-dihydro-1H-imidazol-2-yl)guanidine

: 3282-30-2
pivaloyl chloride

: 1310682-68-8
2,2-dimethyl-propionic acid 2-[N'-(3,4-dichloro-phenyl)-N''-(2,2-dimethyl-propionyl)-guanidino]-1-isopropyl-1H-imidazol-4-yl ester

Guidance literature:: With triethylamine; dmap; In chloroform; at 0 - 20 ℃; for 2h; Inert atmosphere;

Reference yield: 95.0%

: 1310682-45-1
N-(3,4-dichlorophenyl)-N'-(1-isopropyl-4-oxo-4,5-dihydro-1H-imidazol-2-yl)guanidine

: 3282-30-2
pivaloyl chloride

: 1310682-68-8
2,2-dimethylpropionic acid 2-[N'-(3,4-dichlorophenyl)-N''-(2,2-dimethylpropionyl)guanidino]-1-isopropyl-1H-imidazol-4-yl ester

Guidance literature:: With dmap; triethylamine; In chloroform; at 0 - 25 ℃; for 2h; Inert atmosphere;
DOI:10.1021/jm200111g

Reference yield:

: 3183-21-9
2-(2-propylamino)acetic acid

: 1310682-68-8
2,2-dimethylpropionic acid 2-[N'-(3,4-dichlorophenyl)-N''-(2,2-dimethylpropionyl)guanidino]-1-isopropyl-1H-imidazol-4-yl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 140 °C / Inert atmosphere

2: N,N-dimethyl-formamide / Inert atmosphere

3: water / Alkaline conditions; Cooling with ice; Inert atmosphere

4: ethanol / Inert atmosphere; Heating

5: dmap; triethylamine / chloroform / 2 h / 0 - 25 °C / Inert atmosphere

With dmap; triethylamine; In ethanol; chloroform; water; N,N-dimethyl-formamide;
DOI:10.1021/jm200111g