3,3,3-trifluoro-2-hydroxy-N-(4-methoxybenzyl)-2-(4-phenoxyphenyl)propanamide

Base Information

Chemical Name:3,3,3-trifluoro-2-hydroxy-N-(4-methoxybenzyl)-2-(4-phenoxyphenyl)propanamide
CAS No.:1414962-85-8
Molecular Formula:C₂₃H₂₀F₃NO₄
Molecular Weight:431.411
Hs Code.:

Synonyms:3,3,3-trifluoro-2-hydroxy-N-(4-methoxybenzyl)-2-(4-phenoxyphenyl)propanamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3,3,3-trifluoro-2-hydroxy-N-(4-methoxybenzyl)-2-(4-phenoxyphenyl)propanamide

Chemical Property:

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Technology Process of 3,3,3-trifluoro-2-hydroxy-N-(4-methoxybenzyl)-2-(4-phenoxyphenyl)propanamide

There total 5 articles about 3,3,3-trifluoro-2-hydroxy-N-(4-methoxybenzyl)-2-(4-phenoxyphenyl)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 1197-58-6
1-(isocyanomethyl)-4-methoxybenzene

: 70783-32-3
2,2,2-trifluoro-1-(4-phenoxyphenyl)-ethanone

: 64-19-7,77671-22-8
acetic acid

: 1414962-85-8
3,3,3-trifluoro-2-hydroxy-N-(4-methoxybenzyl)-2-(4-phenoxyphenyl)propanamide

Guidance literature:: 1-(isocyanomethyl)-4-methoxybenzene; 2,2,2-trifluoro-1-(4-phenoxyphenyl)-ethanone; acetic acid; at 40 ℃; for 0.666667h; Sonication; Green chemistry;

With water; sodium hydroxide; In methanol; Sonication; Green chemistry;
DOI:10.1039/c2gc36095k

Reference yield:

: C₂₅H₂₂F₃NO₅

: 1414962-85-8
3,3,3-trifluoro-2-hydroxy-N-(4-methoxybenzyl)-2-(4-phenoxyphenyl)propanamide

Guidance literature:: With water; sodium hydroxide; In methanol; at 40 ℃; for 0.333333h; Microwave irradiation;
DOI:10.1021/co400111r

Reference yield:

: 70783-32-3
2,2,2-trifluoro-1-(4-phenoxyphenyl)-ethanone

: 64-19-7,77671-22-8
acetic acid

: 104-47-2
p-methoxybenzylnitrile

: 1414962-85-8
3,3,3-trifluoro-2-hydroxy-N-(4-methoxybenzyl)-2-(4-phenoxyphenyl)propanamide

Guidance literature:: 2,2,2-trifluoro-1-(4-phenoxyphenyl)-ethanone; acetic acid; p-methoxybenzylnitrile; at 40 ℃; for 0.333333h; Sonication;

With water; sodium hydroxide; In methanol; at 20 ℃; for 0.25h; Sonication;
DOI:10.1016/j.molstruc.2016.09.020