1-Benzyl-6-ethyl-5-methyl-4-oxo-7-phenyl-4,6-dihydro-1H-pyrrolo[3,4-b]pyridine-3-carboxylic acid ethyl ester

Base Information

• Chemical Name: 1-Benzyl-6-ethyl-5-methyl-4-oxo-7-phenyl-4,6-dihydro-1H-pyrrolo[3,4-b]pyridine-3-carboxylic acid ethyl ester
• CAS No.: 100856-34-6
• Molecular Formula: C₂₆H₂₆N₂O₃
• Molecular Weight: 414.504

Synonyms:1-Benzyl-6-ethyl-5-methyl-4-oxo-7-phenyl-4,6-dihydro-1H-pyrrolo[3,4-b]pyridine-3-carboxylic acid ethyl ester

Chemical Property of 1-Benzyl-6-ethyl-5-methyl-4-oxo-7-phenyl-4,6-dihydro-1H-pyrrolo[3,4-b]pyridine-3-carboxylic acid ethyl ester

Chemical Property:

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Technology Process of 1-Benzyl-6-ethyl-5-methyl-4-oxo-7-phenyl-4,6-dihydro-1H-pyrrolo[3,4-b]pyridine-3-carboxylic acid ethyl ester

There total 6 articles about 1-Benzyl-6-ethyl-5-methyl-4-oxo-7-phenyl-4,6-dihydro-1H-pyrrolo[3,4-b]pyridine-3-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-benzyl-3-carbethoxy-5-methyl-7-phenyl-1,4-dihydro-4-oxopyrrolo<3,4-b>pyridine (100856-26-6) + ethyl iodide (75-03-6) → 1-Benzyl-6-ethyl-5-methyl-4-oxo-7-phenyl-4,6-dihydro-1H-pyrrolo[3,4-b]pyridine-3-carboxylic acid ethyl ester (100856-34-6)

Guidance literature:

With sodium methylate; In N,N-dimethyl-formamide; r.t., overnight;

DOI:10.1002/jhet.5570220323

Reference yield:

benzyl bromide (100-39-0) → 1-Benzyl-6-ethyl-5-methyl-4-oxo-7-phenyl-4,6-dihydro-1H-pyrrolo[3,4-b]pyridine-3-carboxylic acid ethyl ester (100856-34-6)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydride (60 percent) / tetrahydrofuran / 1.) reflux, 4 hrs., 2.) r.t., overnight

2: polyphosphoric ester / 2 h / 100 - 110 °C

3: 100 percent / sodium methoxide / dimethylformamide / r.t., overnight

With polyphosphoric ester; sodium methylate; sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1002/jhet.5570220323

Reference yield:

N-<2-phenyl-5-methylpyrrol-3-yl>aminomethylenemalonic acid, diethyl ester (100856-21-1) → 1-Benzyl-6-ethyl-5-methyl-4-oxo-7-phenyl-4,6-dihydro-1H-pyrrolo[3,4-b]pyridine-3-carboxylic acid ethyl ester (100856-34-6)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydride (60 percent) / tetrahydrofuran / 1.) reflux, 4 hrs., 2.) r.t., overnight

2: polyphosphoric ester / 2 h / 100 - 110 °C

3: 100 percent / sodium methoxide / dimethylformamide / r.t., overnight

With polyphosphoric ester; sodium methylate; sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1002/jhet.5570220323

upstream raw materials:

1-benzyl-3-carbethoxy-5-methyl-7-phenyl-1,4-dihydro-4-oxopyrrolo<3,4-b>pyridine

ethyl iodide

benzyl bromide

N-<2-phenyl-5-methylpyrrol-3-yl>aminomethylenemalonic acid, diethyl ester

Downstream raw materials:

1-Benzyl-6-ethyl-5-methyl-4-oxo-7-phenyl-4,6-dihydro-1H-pyrrolo[3,4-b]pyridine-3-carboxylic acid

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