1-Cyclopropyl-3-(2,3-difluoro-4-(2-(5-formylpyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)urea

Base Information

Chemical Name:1-Cyclopropyl-3-(2,3-difluoro-4-(2-(5-formylpyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)urea
CAS No.:1342828-76-5
Molecular Formula:C₂₃H₁₆F₂N₄O₃S
Molecular Weight:466.468
Hs Code.:

Synonyms:1-Cyclopropyl-3-(2,3-difluoro-4-(2-(5-formylpyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)urea

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Chemical Property of 1-Cyclopropyl-3-(2,3-difluoro-4-(2-(5-formylpyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)urea

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Technology Process of 1-Cyclopropyl-3-(2,3-difluoro-4-(2-(5-formylpyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)urea

There total 5 articles about 1-Cyclopropyl-3-(2,3-difluoro-4-(2-(5-formylpyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1342836-73-0
1-(4-(2-(5-(1,3-Dioxolan-2-yl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)-2,3-difluorophenyl)-3-cyclopropylurea

: 1342828-76-5
1-Cyclopropyl-3-(2,3-difluoro-4-(2-(5-formylpyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)urea

Guidance literature:: With hydrogenchloride; In tetrahydrofuran;

Reference yield:

: 149806-06-4
6-bromonicotinaldehyde

: 1342828-76-5
1-Cyclopropyl-3-(2,3-difluoro-4-(2-(5-formylpyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)urea

Guidance literature:: Multi-step reaction with 5 steps

1: toluene-4-sulfonic acid / toluene; ethylene glycol

2: n-butyllithium / zinc(II) chloride; Pd(PPh₃)4 / diethyl ether; tetrahydrofuran

3: potassium tert-butylate / dimethyl sulfoxide

4: pyridine / N,N-dimethyl-formamide

5: hydrogenchloride / tetrahydrofuran

With pyridine; hydrogenchloride; n-butyllithium; potassium tert-butylate; toluene-4-sulfonic acid; Pd(PPh₃)4; zinc(II) chloride; In tetrahydrofuran; diethyl ether; ethylene glycol; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;

Reference yield:

: 220904-17-6
2-bromo-5-[1,3]dioxolan-2-yl-pyridine

: 1342828-76-5
1-Cyclopropyl-3-(2,3-difluoro-4-(2-(5-formylpyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)urea

Guidance literature:: Multi-step reaction with 4 steps

1: n-butyllithium / zinc(II) chloride; Pd(PPh₃)4 / diethyl ether; tetrahydrofuran

2: potassium tert-butylate / dimethyl sulfoxide

3: pyridine / N,N-dimethyl-formamide

4: hydrogenchloride / tetrahydrofuran

With pyridine; hydrogenchloride; n-butyllithium; potassium tert-butylate; Pd(PPh₃)4; zinc(II) chloride; In tetrahydrofuran; diethyl ether; dimethyl sulfoxide; N,N-dimethyl-formamide;