4-(2-(5-(1,3-Dioxolan-2-yl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)-2,3-difluoroaniline

Base Information

Chemical Name:4-(2-(5-(1,3-Dioxolan-2-yl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)-2,3-difluoroaniline
CAS No.:1342836-68-3
Molecular Formula:C₂₁H₁₅F₂N₃O₃S
Molecular Weight:427.431
Hs Code.:

Synonyms:4-(2-(5-(1,3-Dioxolan-2-yl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)-2,3-difluoroaniline

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Chemical Property of 4-(2-(5-(1,3-Dioxolan-2-yl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)-2,3-difluoroaniline

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Technology Process of 4-(2-(5-(1,3-Dioxolan-2-yl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)-2,3-difluoroaniline

There total 3 articles about 4-(2-(5-(1,3-Dioxolan-2-yl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)-2,3-difluoroaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1123838-17-4
x

: 163733-99-1
4-amino-2,3-difluoro-phenol

: 1342836-68-3
4-(2-(5-(1,3-Dioxolan-2-yl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)-2,3-difluoroaniline

Guidance literature:: With potassium tert-butylate; In dimethyl sulfoxide;

Reference yield:

: 149806-06-4
6-bromonicotinaldehyde

: 1342836-68-3
4-(2-(5-(1,3-Dioxolan-2-yl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)-2,3-difluoroaniline

Guidance literature:: Multi-step reaction with 3 steps

1: toluene-4-sulfonic acid / toluene; ethylene glycol

2: n-butyllithium / zinc(II) chloride; Pd(PPh₃)4 / diethyl ether; tetrahydrofuran

3: potassium tert-butylate / dimethyl sulfoxide

With n-butyllithium; potassium tert-butylate; toluene-4-sulfonic acid; Pd(PPh₃)4; zinc(II) chloride; In tetrahydrofuran; diethyl ether; ethylene glycol; dimethyl sulfoxide; toluene;

Reference yield:

: 220904-17-6
2-bromo-5-[1,3]dioxolan-2-yl-pyridine

: 1342836-68-3
4-(2-(5-(1,3-Dioxolan-2-yl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)-2,3-difluoroaniline

Guidance literature:: Multi-step reaction with 2 steps

1: n-butyllithium / zinc(II) chloride; Pd(PPh₃)4 / diethyl ether; tetrahydrofuran

2: potassium tert-butylate / dimethyl sulfoxide

With n-butyllithium; potassium tert-butylate; Pd(PPh₃)4; zinc(II) chloride; In tetrahydrofuran; diethyl ether; dimethyl sulfoxide;