1-(4-(2-(5-(1,3-Dioxolan-2-yl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)-2,3-difluorophenyl)-3-cyclopropylurea

Base Information

Chemical Name:1-(4-(2-(5-(1,3-Dioxolan-2-yl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)-2,3-difluorophenyl)-3-cyclopropylurea
CAS No.:1342836-73-0
Molecular Formula:C₂₅H₂₀F₂N₄O₄S
Molecular Weight:510.521
Hs Code.:

Synonyms:1-(4-(2-(5-(1,3-Dioxolan-2-yl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)-2,3-difluorophenyl)-3-cyclopropylurea

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Chemical Property of 1-(4-(2-(5-(1,3-Dioxolan-2-yl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)-2,3-difluorophenyl)-3-cyclopropylurea

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Technology Process of 1-(4-(2-(5-(1,3-Dioxolan-2-yl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)-2,3-difluorophenyl)-3-cyclopropylurea

There total 4 articles about 1-(4-(2-(5-(1,3-Dioxolan-2-yl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)-2,3-difluorophenyl)-3-cyclopropylurea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1342836-68-3
4-(2-(5-(1,3-Dioxolan-2-yl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)-2,3-difluoroaniline

: 1885-14-9
phenyl chloroformate

: 765-30-0
Cyclopropylamine

: 1342836-73-0
1-(4-(2-(5-(1,3-Dioxolan-2-yl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)-2,3-difluorophenyl)-3-cyclopropylurea

Guidance literature:: With pyridine; In N,N-dimethyl-formamide;

Reference yield:

: 220904-17-6
2-bromo-5-[1,3]dioxolan-2-yl-pyridine

: 1342836-73-0
1-(4-(2-(5-(1,3-Dioxolan-2-yl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)-2,3-difluorophenyl)-3-cyclopropylurea

Guidance literature:: Multi-step reaction with 3 steps

1: n-butyllithium / zinc(II) chloride; Pd(PPh₃)4 / diethyl ether; tetrahydrofuran

2: potassium tert-butylate / dimethyl sulfoxide

3: pyridine / N,N-dimethyl-formamide

With pyridine; n-butyllithium; potassium tert-butylate; Pd(PPh₃)4; zinc(II) chloride; In tetrahydrofuran; diethyl ether; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 149806-06-4
6-bromonicotinaldehyde

: 1342836-73-0
1-(4-(2-(5-(1,3-Dioxolan-2-yl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)-2,3-difluorophenyl)-3-cyclopropylurea

Guidance literature:: Multi-step reaction with 4 steps

1: toluene-4-sulfonic acid / toluene; ethylene glycol

2: n-butyllithium / zinc(II) chloride; Pd(PPh₃)4 / diethyl ether; tetrahydrofuran

3: potassium tert-butylate / dimethyl sulfoxide

4: pyridine / N,N-dimethyl-formamide

With pyridine; n-butyllithium; potassium tert-butylate; toluene-4-sulfonic acid; Pd(PPh₃)4; zinc(II) chloride; In tetrahydrofuran; diethyl ether; ethylene glycol; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;