phenylmethyl 7-hydroxy-5,12-dioxa-9-azadispiro[2.2.5.2]tridecane-9-carboxylate

Base Information

Chemical Name:phenylmethyl 7-hydroxy-5,12-dioxa-9-azadispiro[2.2.5.2]tridecane-9-carboxylate
CAS No.:1431285-73-2
Molecular Formula:C₁₈H₂₃NO₅
Molecular Weight:333.384
Hs Code.:

Synonyms:phenylmethyl 7-hydroxy-5,12-dioxa-9-azadispiro[2.2.5.2]tridecane-9-carboxylate

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Chemical Property of phenylmethyl 7-hydroxy-5,12-dioxa-9-azadispiro[2.2.5.2]tridecane-9-carboxylate

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Technology Process of phenylmethyl 7-hydroxy-5,12-dioxa-9-azadispiro[2.2.5.2]tridecane-9-carboxylate

There total 3 articles about phenylmethyl 7-hydroxy-5,12-dioxa-9-azadispiro[2.2.5.2]tridecane-9-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1431285-72-1
phenylmethyl 7-[(phenylcarbonyl)oxy]-5,12-dioxa-9-azadispiro[2.2.5.2]tridecane-9-carboxylate

: 1431285-73-2
phenylmethyl 7-hydroxy-5,12-dioxa-9-azadispiro[2.2.5.2]tridecane-9-carboxylate

Guidance literature:: With lithium hydroxide monohydrate; In tetrahydrofuran; methanol; water; at 20 ℃; for 6.5h;
DOI:10.1021/jm400125h

Reference yield:

: 19099-93-5
benzyl 4-oxo-1-piperidinecarboxylate

: 1431285-73-2
phenylmethyl 7-hydroxy-5,12-dioxa-9-azadispiro[2.2.5.2]tridecane-9-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: dimethyl sulfoxide / 4 h / 20 °C

2: toluene-4-sulfonic acid / toluene / 24 h / 140 °C / Dean-Stark

3: lithium hydroxide monohydrate / water; tetrahydrofuran; methanol / 6.5 h / 20 °C

With lithium hydroxide monohydrate; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; water; dimethyl sulfoxide; toluene;
DOI:10.1021/jm400125h

Reference yield:

: 1431285-71-0
phenylmethyl 4-oxo-3-[(phenylcarbonyl)oxy]-1-piperidinecarboxylate

: 1431285-73-2
phenylmethyl 7-hydroxy-5,12-dioxa-9-azadispiro[2.2.5.2]tridecane-9-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: toluene-4-sulfonic acid / toluene / 24 h / 140 °C / Dean-Stark

2: lithium hydroxide monohydrate / water; tetrahydrofuran; methanol / 6.5 h / 20 °C

With lithium hydroxide monohydrate; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; water; toluene;
DOI:10.1021/jm400125h