phenylmethyl 7-[(phenylcarbonyl)oxy]-5,12-dioxa-9-azadispiro[2.2.5.2]tridecane-9-carboxylate

Base Information

• Chemical Name: phenylmethyl 7-[(phenylcarbonyl)oxy]-5,12-dioxa-9-azadispiro[2.2.5.2]tridecane-9-carboxylate
• CAS No.: 1431285-72-1
• Molecular Formula: C₂₅H₂₇NO₆
• Molecular Weight: 437.492
• Mol file: 1431285-72-1.mol

Synonyms:phenylmethyl 7-[(phenylcarbonyl)oxy]-5,12-dioxa-9-azadispiro[2.2.5.2]tridecane-9-carboxylate

Chemical Property of phenylmethyl 7-[(phenylcarbonyl)oxy]-5,12-dioxa-9-azadispiro[2.2.5.2]tridecane-9-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of phenylmethyl 7-[(phenylcarbonyl)oxy]-5,12-dioxa-9-azadispiro[2.2.5.2]tridecane-9-carboxylate

There total 3 articles about phenylmethyl 7-[(phenylcarbonyl)oxy]-5,12-dioxa-9-azadispiro[2.2.5.2]tridecane-9-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

[1-(hydroxymethyl)cyclopropyl]methanol (39590-81-3) + phenylmethyl 4-oxo-3-[(phenylcarbonyl)oxy]-1-piperidinecarboxylate (1431285-71-0) → phenylmethyl 7-[(phenylcarbonyl)oxy]-5,12-dioxa-9-azadispiro[2.2.5.2]tridecane-9-carboxylate (1431285-72-1)

Guidance literature:

With toluene-4-sulfonic acid; In toluene; at 140 ℃; for 24h; Dean-Stark;

DOI:10.1021/jm400125h

Reference yield:

benzyl 4-oxo-1-piperidinecarboxylate (19099-93-5) → phenylmethyl 7-[(phenylcarbonyl)oxy]-5,12-dioxa-9-azadispiro[2.2.5.2]tridecane-9-carboxylate (1431285-72-1)

Guidance literature:

Multi-step reaction with 2 steps

1: dimethyl sulfoxide / 4 h / 20 °C

2: toluene-4-sulfonic acid / toluene / 24 h / 140 °C / Dean-Stark

With toluene-4-sulfonic acid; In dimethyl sulfoxide; toluene;

DOI:10.1021/jm400125h

Reference yield:

N-methyl-O-(phenylcarbonyl)hydroxylamine hydrochloride (27130-46-7) → phenylmethyl 7-[(phenylcarbonyl)oxy]-5,12-dioxa-9-azadispiro[2.2.5.2]tridecane-9-carboxylate (1431285-72-1)

Guidance literature:

Multi-step reaction with 2 steps

1: dimethyl sulfoxide / 4 h / 20 °C

2: toluene-4-sulfonic acid / toluene / 24 h / 140 °C / Dean-Stark

With toluene-4-sulfonic acid; In dimethyl sulfoxide; toluene;

DOI:10.1021/jm400125h

upstream raw materials:

benzyl 4-oxo-1-piperidinecarboxylate

[1-(hydroxymethyl)cyclopropyl]methanol

phenylmethyl 4-oxo-3-[(phenylcarbonyl)oxy]-1-piperidinecarboxylate

N-methyl-O-(phenylcarbonyl)hydroxylamine hydrochloride

Downstream raw materials:

phenylmethyl 7-hydroxy-5,12-dioxa-9-azadispiro[2.2.5.2]tridecane-9-carboxylate

5,12-dioxa-9-azadispiro[2.2.5.2]tridec-7-yl benzoate

9-{[3-chloro-5-cyclopropyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyridin-2-yl]carbonyl}-5,12-dioxa-9-azadispiro[2.2.5.2]tridec-7-yl benzoate

C₁₇H₂₁NO₄