4,4-dimethyl-5'-phenyl-2'-(phenyl-trimethylsilanyloxy-methyl)-4,5-dihydro-[2,4']bioxazolyl

Base Information

Chemical Name:4,4-dimethyl-5'-phenyl-2'-(phenyl-trimethylsilanyloxy-methyl)-4,5-dihydro-[2,4']bioxazolyl
CAS No.:1026936-09-3
Molecular Formula:C₂₄H₂₈N₂O₃Si
Molecular Weight:420.583
Hs Code.:

Synonyms:4,4-dimethyl-5'-phenyl-2'-(phenyl-trimethylsilanyloxy-methyl)-4,5-dihydro-[2,4']bioxazolyl

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Chemical Property of 4,4-dimethyl-5'-phenyl-2'-(phenyl-trimethylsilanyloxy-methyl)-4,5-dihydro-[2,4']bioxazolyl

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Technology Process of 4,4-dimethyl-5'-phenyl-2'-(phenyl-trimethylsilanyloxy-methyl)-4,5-dihydro-[2,4']bioxazolyl

There total 7 articles about 4,4-dimethyl-5'-phenyl-2'-(phenyl-trimethylsilanyloxy-methyl)-4,5-dihydro-[2,4']bioxazolyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 100-52-7
benzaldehyde

: 1026936-09-3
4,4-dimethyl-5'-phenyl-2'-(phenyl-trimethylsilanyloxy-methyl)-4,5-dihydro-[2,4']bioxazolyl

Guidance literature:: Multi-step reaction with 2 steps

1: 64 percent / n-BuLi / tetrahydrofuran; hexane / 1 h / -78 - 20 °C

2: I₂ / CH₂Cl₂ / 3 h

With n-butyllithium; iodine; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/jo010762s

Reference yield:

: 32998-97-3
ethyl 5-phenyl-1,3-oxazole-4-carboxylate

: 1026936-09-3
4,4-dimethyl-5'-phenyl-2'-(phenyl-trimethylsilanyloxy-methyl)-4,5-dihydro-[2,4']bioxazolyl

Guidance literature:: Multi-step reaction with 6 steps

1: 91 percent / aq. NaOH / ethanol / 12 h / 20 °C

2: SOCl₂ / 3 h / Heating

3: Et₃N / CH₂Cl₂ / 3 h / 20 °C

4: 8.3 g / SOCl₂ / CH₂Cl₂ / 4 h / 20 °C

5: 64 percent / n-BuLi / tetrahydrofuran; hexane / 1 h / -78 - 20 °C

6: I₂ / CH₂Cl₂ / 3 h

With sodium hydroxide; n-butyllithium; thionyl chloride; iodine; triethylamine; In tetrahydrofuran; ethanol; hexane; dichloromethane;
DOI:10.1021/jo010762s

Reference yield:

: 99924-18-2
5-phenyl-1,3-oxazole-4-carboxylic acid

: 1026936-09-3
4,4-dimethyl-5'-phenyl-2'-(phenyl-trimethylsilanyloxy-methyl)-4,5-dihydro-[2,4']bioxazolyl

Guidance literature:: Multi-step reaction with 5 steps

1: SOCl₂ / 3 h / Heating

2: Et₃N / CH₂Cl₂ / 3 h / 20 °C

3: 8.3 g / SOCl₂ / CH₂Cl₂ / 4 h / 20 °C

4: 64 percent / n-BuLi / tetrahydrofuran; hexane / 1 h / -78 - 20 °C

5: I₂ / CH₂Cl₂ / 3 h

With n-butyllithium; thionyl chloride; iodine; triethylamine; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/jo010762s