((3aR,4R,6R,6aR)-2,2-dimethyl-6-(6-(phenethylamino)-9H-purin-9-yl)-tetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methanol

Base Information

Chemical Name:((3aR,4R,6R,6aR)-2,2-dimethyl-6-(6-(phenethylamino)-9H-purin-9-yl)-tetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methanol
CAS No.:901776-23-6
Molecular Formula:C₂₁H₂₅N₅O₄
Molecular Weight:411.461
Hs Code.:

Synonyms:((3aR,4R,6R,6aR)-2,2-dimethyl-6-(6-(phenethylamino)-9H-purin-9-yl)-tetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methanol

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Chemical Property of ((3aR,4R,6R,6aR)-2,2-dimethyl-6-(6-(phenethylamino)-9H-purin-9-yl)-tetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methanol

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Technology Process of ((3aR,4R,6R,6aR)-2,2-dimethyl-6-(6-(phenethylamino)-9H-purin-9-yl)-tetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methanol

There total 1 articles about ((3aR,4R,6R,6aR)-2,2-dimethyl-6-(6-(phenethylamino)-9H-purin-9-yl)-tetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 20125-39-7
N6-(2-phenylethyl)adenosine

: 77-76-9
2,2-dimethoxy-propane

: 901776-23-6
((3aR,4R,6R,6aR)-2,2-dimethyl-6-(6-(phenethylamino)-9H-purin-9-yl)-tetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methanol

Guidance literature:: N₆-(2-phenylethyl)adenosine; 2,2-dimethoxy-propane; With toluene-4-sulfonic acid; In acetone; at 20 ℃; for 3h;

With triethylamine; In acetone;

Reference yield: 82.0%

: 901776-23-6
((3aR,4R,6R,6aR)-2,2-dimethyl-6-(6-(phenethylamino)-9H-purin-9-yl)-tetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methanol

: 2′,3′-O-isopropylidene-6-phenethylamino-5′-O,8-cycloadenosine

Guidance literature:: With di-tert-butyl peroxide; copper(l) chloride; In N,N-dimethyl-formamide; at 80 ℃; for 12h; under 760.051 Torr; Sealed tube;
DOI:10.1021/acs.joc.5b01360

Reference yield: 43.0%

: 901776-23-6
((3aR,4R,6R,6aR)-2,2-dimethyl-6-(6-(phenethylamino)-9H-purin-9-yl)-tetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methanol

: 124-41-4
sodium methylate

: 130288-32-3
tert-butyl (2-oxotetrahydrothiophen-3-yl)carbamate

: 901776-24-7
methyl 2-(tert-butoxycarbonylamino)-4-(((3aS,4S,6R,6aR)-2,2-dimethyl-6-(6-(phenethylamino)-9H-purin-9-yl)-tetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methylthio)butanoate

Guidance literature:: ((3aR,4R,6R,6aR)-2,2-dimethyl-6-(6-(phenethylamino)-9H-purin-9-yl)-tetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methanol; With sodium hydride; In tetrahydrofuran; at 0 ℃; for 0.25h;

With p-toluenesulfonyl chloride; In tetrahydrofuran; at 0 ℃; for 1h;

sodium methylate; tert-butyl (2-oxotetrahydrothiophen-3-yl)carbamate; In methanol; at 20 ℃; for 4.25h; Heating / reflux;