2,4-DIAMINOQUINAZOLINE

Base Information

• Chemical Name: 2,4-DIAMINOQUINAZOLINE
• CAS No.: 1899-48-5
• Molecular Formula: C8H8N4
• Molecular Weight: 160.178
• Mol file: 1899-48-5.mol

Synonyms:Quinazoline,2,4-diamino- (6CI,7CI,8CI);2,4-Diaminoquinazoline;NSC 403373;SRI 93;

Chemical Property of 2,4-DIAMINOQUINAZOLINE

Chemical Property:

• Appearance/Colour: solid
• Vapor Pressure: 1.11E-08mmHg at 25°C
• Melting Point: 254-258 °C
• Refractive Index: 1.795
• Boiling Point: 461 °C at 760 mmHg
• Flash Point: 263.5 °C
• PSA: 77.82000
• Density: 1.398 g/cm³
• LogP: 1.95660
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

98%min ^*data from raw suppliers

Quinazoline-2,4-diamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): R36/37/38:Irritating to eyes, respiratory system and skin.
• Hazard Codes: T
• Statements: 36/37/38-36-25
• Safety Statements: 26-36-45

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,4-DIAMINOQUINAZOLINE

There total 19 articles about 2,4-DIAMINOQUINAZOLINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

guanidine carbonate (593-85-1,90332-86-8,3425-08-9) + 2-fluorobenzonitrile (394-47-8) → 2,4-diaminoquinazoline (1899-48-5)

Guidance literature:

In N,N-dimethyl acetamide; at 150 ℃; for 14h;

DOI:10.1021/acsmedchemlett.6b00039

Reference yield: 80.0%

guanidine carbonate (593-85-1,90332-86-8,3425-08-9) + anthranilic acid nitrile (1885-29-6) → 2,4-diaminoquinazoline (1899-48-5)

Guidance literature:

In N,N-dimethyl acetamide; at 150 ℃; for 14h;

DOI:10.1021/acsmedchemlett.6b00039

Reference yield: 79.0%

2-fluorobenzonitrile (394-47-8) + guanidine nitrate (113-00-8) → 2,4-diaminoquinazoline (1899-48-5)

Guidance literature:

With sodium carbonate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl acetamide; at 125 ℃; for 3h; Reagent/catalyst; Temperature;

DOI:10.1039/c5ra03510d

upstream raw materials:

quinazoline

N,N-dimethyl-aniline

2,4-dichloroquinazoline

2,4-bis(methylthio)quinazoline

Downstream raw materials:

N²,N⁴-dibenzylquinazoline-2,4-diamine

Refernces

• 1、 Vopicka,Lange. "-". . p. 1068. Retrieved 1935.
• 2、 Shelke, Nilesh B.,Ghorpade, Ramrao,Pratap, Ajay,Tak, Vijay,Acharya. "SNAr reaction in aqueous medium in the presence of mixed organic and inorganic bases". . p. 31226 - 31230. Retrieved 2015/04/22.