Technology Process of 3-(4-hydroxymethyl-2-phenyl-4,5-dihydro-oxazol-5-yl)-N-methoxy-N-methyl-propionamide
There total 10 articles about 3-(4-hydroxymethyl-2-phenyl-4,5-dihydro-oxazol-5-yl)-N-methoxy-N-methyl-propionamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: O3 / methanol / -78 °C
2.1: LiCl; DBU / acetonitrile / 1 h
2.2: 2.03 g / acetonitrile / 2 h
3.1: 82.4 percent / CuBr; Red-Al; 2-butanol / tetrahydrofuran / 4 h / -20 °C
4.1: aq. LiOH / tetrahydrofuran / 2 h
5.1: 491 mg / Et3N; DCC; HOBt / CH2Cl2 / 12 h
6.1: 94 percent / TBAF / tetrahydrofuran / 1 h / 20 °C
With
lithium hydroxide; tetrabutyl ammonium fluoride; benzotriazol-1-ol; ozone; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; dicyclohexyl-carbodiimide; sodium bis(2-methoxyethoxy)aluminium dihydride; iso-butanol; lithium chloride; copper(I) bromide;
In
tetrahydrofuran; methanol; dichloromethane; acetonitrile;
DOI:10.1016/S0957-4166(02)00794-2
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: 99 percent / pyridine / CH2Cl2 / 12 h
2.1: 75 percent / K2CO3; Pd(PPh3)4 / acetonitrile / 24 h / Heating
3.1: O3 / methanol / -78 °C
4.1: LiCl; DBU / acetonitrile / 1 h
4.2: 2.03 g / acetonitrile / 2 h
5.1: 82.4 percent / CuBr; Red-Al; 2-butanol / tetrahydrofuran / 4 h / -20 °C
6.1: aq. LiOH / tetrahydrofuran / 2 h
7.1: 491 mg / Et3N; DCC; HOBt / CH2Cl2 / 12 h
8.1: 94 percent / TBAF / tetrahydrofuran / 1 h / 20 °C
With
pyridine; lithium hydroxide; tetrakis(triphenylphosphine) palladium(0); tetrabutyl ammonium fluoride; potassium carbonate; benzotriazol-1-ol; ozone; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; dicyclohexyl-carbodiimide; sodium bis(2-methoxyethoxy)aluminium dihydride; iso-butanol; lithium chloride; copper(I) bromide;
In
tetrahydrofuran; methanol; dichloromethane; acetonitrile;
DOI:10.1016/S0957-4166(02)00794-2
