4-(4-methoxyphenyl)-5-[(Z)-(4-methoxyphenyl)methylidene]furan-2-one

Base Information

• Chemical Name: 4-(4-methoxyphenyl)-5-[(Z)-(4-methoxyphenyl)methylidene]furan-2-one
• CAS No.: 216227-78-0
• Molecular Formula: C₁₉H₁₆O₄
• Molecular Weight: 308.334
• Mol file: 216227-78-0.mol

Synonyms:4-(4-methoxyphenyl)-5-[(Z)-(4-methoxyphenyl)methylidene]furan-2-one

Chemical Property of 4-(4-methoxyphenyl)-5-[(Z)-(4-methoxyphenyl)methylidene]furan-2-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(4-methoxyphenyl)-5-[(Z)-(4-methoxyphenyl)methylidene]furan-2-one

There total 16 articles about 4-(4-methoxyphenyl)-5-[(Z)-(4-methoxyphenyl)methylidene]furan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

4-(4-methoxyphenyl)furan-2(5H)-one (3516-65-2) + 4-methoxy-benzaldehyde (123-11-5) → 4-(4-methoxyphenyl)-5-[(Z)-(4-methoxyphenyl)methylidene]furan-2-one (216227-78-0)

Guidance literature:

With piperidine; In methanol; at 25 - 30 ℃; for 15h; Inert atmosphere;

DOI:10.1016/j.tetlet.2016.11.096

Reference yield: 78.0%

(5Z)-4-bromo-5-(bromomethylene)-2-(5H)-furanone (32323-47-0,247167-54-0) + 4-methoxyphenylboronic acid (5720-07-0) → 4-(4-methoxyphenyl)-5-[(Z)-(4-methoxyphenyl)methylidene]furan-2-one (216227-78-0)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetrabutylammomium bromide; sodium carbonate; In water; toluene; for 2h; Inert atmosphere; Reflux;

DOI:10.1016/j.bioorg.2020.104376

Reference yield:

C19H20O4 → 4-(4-methoxyphenyl)-5-[(Z)-(4-methoxyphenyl)methylidene]furan-2-one (216227-78-0)

Guidance literature:

With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In benzene; at 90 ℃; for 4h; stereoselective reaction; Inert atmosphere;

DOI:10.1021/acs.orglett.1c01529

upstream raw materials:

4-(4-methoxyphenyl)furan-2(5H)-one

4-methoxy-benzaldehyde

3-(4-methoxyphenyl)-2,5-dihydrofuran-2,5-dione

(Z)-2-(4-methoxyphenyl)but-2-enedioic acid

Downstream raw materials:

rubrolide E diacetate

4-(4-hydroxyphenyl)-5-[(Z)-(4-hydroxyphenyl)methylidene]furan-2-one