Technology Process of (3S)-8-(benzyloxy)oct-1-en-3-ol
There total 8 articles about (3S)-8-(benzyloxy)oct-1-en-3-ol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 - 20 °C
1.2: 20 °C
2.1: triethylamine; oxalyl dichloride; dimethyl sulfoxide / dichloromethane / -78 °C
3.1: benzene / 0.5 h / Reflux
4.1: diisobutylaluminium hydride / tetrahydrofuran; toluene / 0.5 h / -10 - 0 °C
5.1: titanium(IV) isopropylate; diethyl (2S,3S)-tartrate / dichloromethane / 0.5 h / -30 °C / Molecular sieve
5.2: 4 h / -30 °C / Molecular sieve
6.1: 1H-imidazole; triphenylphosphine; iodine / tetrahydrofuran / 1.08 h / 0 - 20 °C
7.1: zinc / methanol / 6 h / Reflux
With
1H-imidazole; titanium(IV) isopropylate; oxalyl dichloride; diethyl (2S,3S)-tartrate; iodine; sodium hydride; diisobutylaluminium hydride; dimethyl sulfoxide; triethylamine; triphenylphosphine; zinc;
In
tetrahydrofuran; methanol; dichloromethane; toluene; mineral oil; benzene;
2.1: |Swern Oxidation / 3.1: |Wittig Olefination / 5.1: |Sharpless Asymmetric Epoxidation / 5.2: |Sharpless Asymmetric Epoxidation;
DOI:10.1002/hlca.201300223
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 - 20 °C
1.2: 20 °C
2.1: triethylamine; oxalyl dichloride; dimethyl sulfoxide / dichloromethane / -78 °C
3.1: benzene / 0.5 h / Reflux
4.1: diisobutylaluminium hydride / tetrahydrofuran; toluene / 0.5 h / -10 - 0 °C
5.1: titanium(IV) isopropylate; diethyl (2S,3S)-tartrate / dichloromethane / 0.5 h / -30 °C / Molecular sieve
5.2: 4 h / -30 °C / Molecular sieve
6.1: 1H-imidazole; triphenylphosphine; iodine / tetrahydrofuran / 1.08 h / 0 - 20 °C
7.1: zinc / methanol / 6 h / Reflux
With
1H-imidazole; titanium(IV) isopropylate; oxalyl dichloride; diethyl (2S,3S)-tartrate; iodine; sodium hydride; diisobutylaluminium hydride; dimethyl sulfoxide; triethylamine; triphenylphosphine; zinc;
In
tetrahydrofuran; methanol; dichloromethane; toluene; mineral oil; benzene;
2.1: |Swern Oxidation / 3.1: |Wittig Olefination / 5.1: |Sharpless Asymmetric Epoxidation / 5.2: |Sharpless Asymmetric Epoxidation;
DOI:10.1002/hlca.201300223
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: diisobutylaluminium hydride / tetrahydrofuran; toluene / 0.5 h / -10 - 0 °C
2.1: titanium(IV) isopropylate; diethyl (2S,3S)-tartrate / dichloromethane / 0.5 h / -30 °C / Molecular sieve
2.2: 4 h / -30 °C / Molecular sieve
3.1: 1H-imidazole; triphenylphosphine; iodine / tetrahydrofuran / 1.08 h / 0 - 20 °C
4.1: zinc / methanol / 6 h / Reflux
With
1H-imidazole; titanium(IV) isopropylate; diethyl (2S,3S)-tartrate; iodine; diisobutylaluminium hydride; triphenylphosphine; zinc;
In
tetrahydrofuran; methanol; dichloromethane; toluene;
2.1: |Sharpless Asymmetric Epoxidation / 2.2: |Sharpless Asymmetric Epoxidation;
DOI:10.1002/hlca.201300223
