7-amino-5-(2-chlorophenyl)-1-(2,6-dichlorophenyl)-3-(4-methoxybenzyl)-3.4-dihydroquinazolin-2(1H)-one

Base Information

Chemical Name:7-amino-5-(2-chlorophenyl)-1-(2,6-dichlorophenyl)-3-(4-methoxybenzyl)-3.4-dihydroquinazolin-2(1H)-one
CAS No.:444665-70-7
Molecular Formula:C₂₈H₂₂Cl₃N₃O₂
Molecular Weight:538.861
Hs Code.:

Synonyms:7-amino-5-(2-chlorophenyl)-1-(2,6-dichlorophenyl)-3-(4-methoxybenzyl)-3.4-dihydroquinazolin-2(1H)-one

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Chemical Property of 7-amino-5-(2-chlorophenyl)-1-(2,6-dichlorophenyl)-3-(4-methoxybenzyl)-3.4-dihydroquinazolin-2(1H)-one

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Technology Process of 7-amino-5-(2-chlorophenyl)-1-(2,6-dichlorophenyl)-3-(4-methoxybenzyl)-3.4-dihydroquinazolin-2(1H)-one

There total 7 articles about 7-amino-5-(2-chlorophenyl)-1-(2,6-dichlorophenyl)-3-(4-methoxybenzyl)-3.4-dihydroquinazolin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 444665-68-3
5-(2-chlorophenyl)-1-(2,6-dichlorophenyl)-3-(4-methoxybenzyl)-7-nitro-3,4-dihydroquinazolin-2(1H)-one

: 444665-70-7
7-amino-5-(2-chlorophenyl)-1-(2,6-dichlorophenyl)-3-(4-methoxybenzyl)-3.4-dihydroquinazolin-2(1H)-one

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethyl acetate;
DOI:10.1016/S0960-894X(02)00990-3

Reference yield:

: 3900-89-8
2-Chlorobenzeneboronic acid

: 444665-70-7
7-amino-5-(2-chlorophenyl)-1-(2,6-dichlorophenyl)-3-(4-methoxybenzyl)-3.4-dihydroquinazolin-2(1H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: aq. Na₂CO₃; Pd(PPh₃)4 / ethanol; toluene / 100 °C

2: H₂ / Pd/C / ethyl acetate

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrogen; sodium carbonate; palladium on activated charcoal; In ethanol; ethyl acetate; toluene; 1: Suzuki coupling;
DOI:10.1016/S0960-894X(02)00990-3

Reference yield:

: 101581-06-0
1,3-dibromo-2-methyl-5-nitrobenzene

: 444665-70-7
7-amino-5-(2-chlorophenyl)-1-(2,6-dichlorophenyl)-3-(4-methoxybenzyl)-3.4-dihydroquinazolin-2(1H)-one

Guidance literature:: Multi-step reaction with 6 steps

1: NBS; AIBN; (BzO)2 / CCl₄

2: K₂CO₃ / dimethylformamide

3: CH₂Cl₂

4: CuI; iPr₂NEt / dimethylformamide / 130 °C

5: aq. Na₂CO₃; Pd(PPh₃)4 / ethanol; toluene / 100 °C

6: H₂ / Pd/C / ethyl acetate

With N-Bromosuccinimide; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 2,2'-azobis(isobutyronitrile); hydrogen; sodium carbonate; potassium carbonate; N-ethyl-N,N-diisopropylamine; dibenzoyl peroxide; palladium on activated charcoal; In tetrachloromethane; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; toluene; 4: Ullmann cyclization / 5: Suzuki coupling;
DOI:10.1016/S0960-894X(02)00990-3