5-(2-chlorophenyl)-1-(2,6-dichlorophenyl)-3-(4-methoxybenzyl)-7-nitro-3,4-dihydroquinazolin-2(1H)-one

Base Information

• Chemical Name: 5-(2-chlorophenyl)-1-(2,6-dichlorophenyl)-3-(4-methoxybenzyl)-7-nitro-3,4-dihydroquinazolin-2(1H)-one
• CAS No.: 444665-68-3
• Molecular Formula: C₂₈H₂₀Cl₃N₃O₄
• Molecular Weight: 568.843
• Mol file: 444665-68-3.mol

Synonyms:5-(2-chlorophenyl)-1-(2,6-dichlorophenyl)-3-(4-methoxybenzyl)-7-nitro-3,4-dihydroquinazolin-2(1H)-one

Chemical Property of 5-(2-chlorophenyl)-1-(2,6-dichlorophenyl)-3-(4-methoxybenzyl)-7-nitro-3,4-dihydroquinazolin-2(1H)-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(2-chlorophenyl)-1-(2,6-dichlorophenyl)-3-(4-methoxybenzyl)-7-nitro-3,4-dihydroquinazolin-2(1H)-one

There total 5 articles about 5-(2-chlorophenyl)-1-(2,6-dichlorophenyl)-3-(4-methoxybenzyl)-7-nitro-3,4-dihydroquinazolin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-Chlorobenzeneboronic acid (3900-89-8) + 5-bromo-1-(2,6-dichlorophenyl)-3-(4-methoxybenzyl)-7-nitro-3,4-dihydroquinazolin-2(1H)-one (444665-67-2) → 5-(2-chlorophenyl)-1-(2,6-dichlorophenyl)-3-(4-methoxybenzyl)-7-nitro-3,4-dihydroquinazolin-2(1H)-one (444665-68-3)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In ethanol; toluene; at 100 ℃;

DOI:10.1016/S0960-894X(02)00990-3

Reference yield:

1,3-dibromo-2-methyl-5-nitrobenzene (101581-06-0) → 5-(2-chlorophenyl)-1-(2,6-dichlorophenyl)-3-(4-methoxybenzyl)-7-nitro-3,4-dihydroquinazolin-2(1H)-one (444665-68-3)

Guidance literature:

Multi-step reaction with 5 steps

1: NBS; AIBN; (BzO)2 / CCl₄

2: K₂CO₃ / dimethylformamide

3: CH₂Cl₂

4: CuI; iPr₂NEt / dimethylformamide / 130 °C

5: aq. Na₂CO₃; Pd(PPh₃)4 / ethanol; toluene / 100 °C

With N-Bromosuccinimide; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 2,2'-azobis(isobutyronitrile); sodium carbonate; potassium carbonate; N-ethyl-N,N-diisopropylamine; dibenzoyl peroxide; In tetrachloromethane; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene; 4: Ullmann cyclization / 5: Suzuki coupling;

DOI:10.1016/S0960-894X(02)00990-3

Reference yield:

1-Bromomethyl-2,6-dibromo-4-nitrobenzene (444664-09-9) → 5-(2-chlorophenyl)-1-(2,6-dichlorophenyl)-3-(4-methoxybenzyl)-7-nitro-3,4-dihydroquinazolin-2(1H)-one (444665-68-3)

Guidance literature:

Multi-step reaction with 4 steps

1: K₂CO₃ / dimethylformamide

2: CH₂Cl₂

3: CuI; iPr₂NEt / dimethylformamide / 130 °C

4: aq. Na₂CO₃; Pd(PPh₃)4 / ethanol; toluene / 100 °C

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; potassium carbonate; N-ethyl-N,N-diisopropylamine; In ethanol; dichloromethane; N,N-dimethyl-formamide; toluene; 3: Ullmann cyclization / 4: Suzuki coupling;

DOI:10.1016/S0960-894X(02)00990-3

upstream raw materials:

2-Chlorobenzeneboronic acid

5-bromo-1-(2,6-dichlorophenyl)-3-(4-methoxybenzyl)-7-nitro-3,4-dihydroquinazolin-2(1H)-one

1,3-dibromo-2-methyl-5-nitrobenzene

1-Bromomethyl-2,6-dibromo-4-nitrobenzene

Downstream raw materials:

5-(2-chlorophenyl)-1-(2,6-dichlorophenyl)-7-nitro-3,4-dihydroquinazolin-2(1H)-one

5-(2-chlorophenyl)-1-(2,6-dichlorophenyl)-7-(piperidin-4-ylamino)-3,4-dihydroquinazolin-2(1H)-one

7-amino-5-(2-chlorophenyl)-1-(2,6-dichlorophenyl)-3-(4-methoxybenzyl)-3.4-dihydroquinazolin-2(1H)-one