N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-2-chloroaniline

Base Information

Chemical Name:N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-2-chloroaniline
CAS No.:1352608-88-8
Molecular Formula:C₂₂H₁₈ClN₇
Molecular Weight:415.885
Hs Code.:

Synonyms:N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-2-chloroaniline

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Chemical Property of N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-2-chloroaniline

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Technology Process of N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-2-chloroaniline

There total 6 articles about N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-2-chloroaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₂H₁₆ClN₇

: 1352608-88-8
N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-2-chloroaniline

Guidance literature:: With sodium tris(acetoxy)borohydride; In tetrahydrofuran; methanol; at 20 ℃; for 3h; Inert atmosphere;
DOI:10.1016/j.bmc.2014.03.022

Reference yield:

: 356560-84-4
1-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-2-(6-methylpyridin-2-yl)ethane-1,2-dione

: 1352608-88-8
N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-2-chloroaniline

Guidance literature:: Multi-step reaction with 4 steps

1: ammonium acetate / methanol; tert-butyl methyl ether; water / 4 h / 20 °C

2: hydrogenchloride / water / 4 h / 70 °C

3: acetic acid / 1,2-dichloro-ethane / 2 h / Reflux; Inert atmosphere

4: sodium tris(acetoxy)borohydride / methanol; tetrahydrofuran / 3 h / 20 °C / Inert atmosphere

With hydrogenchloride; ammonium acetate; sodium tris(acetoxy)borohydride; acetic acid; In tetrahydrofuran; methanol; tert-butyl methyl ether; water; 1,2-dichloro-ethane;
DOI:10.1016/j.bmc.2014.03.022

Reference yield:

: 1352609-89-2
6-(2-(dimethoxymethyl)-5-(6-methylpyridin-2-yl)-1H-imidazol-4-yl)-[1,2,4]triazolo[1,5-a]pyridine

: 1352608-88-8
N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-2-chloroaniline

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / water / 4 h / 70 °C

2: acetic acid / 1,2-dichloro-ethane / 2 h / Reflux; Inert atmosphere

3: sodium tris(acetoxy)borohydride / methanol; tetrahydrofuran / 3 h / 20 °C / Inert atmosphere

With hydrogenchloride; sodium tris(acetoxy)borohydride; acetic acid; In tetrahydrofuran; methanol; water; 1,2-dichloro-ethane;
DOI:10.1016/j.bmc.2014.03.022