N-((tris(4-chlorophenyl)propionyl)glycyl)glycine ethyl ester

Base Information

• Chemical Name: N-((tris(4-chlorophenyl)propionyl)glycyl)glycine ethyl ester
• CAS No.: 556810-25-4
• Molecular Formula: C₂₇H₂₅Cl₃N₂O₄
• Molecular Weight: 547.865
• Mol file: 556810-25-4.mol

Synonyms:N-((tris(4-chlorophenyl)propionyl)glycyl)glycine ethyl ester

Chemical Property of N-((tris(4-chlorophenyl)propionyl)glycyl)glycine ethyl ester

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of N-((tris(4-chlorophenyl)propionyl)glycyl)glycine ethyl ester

There total 2 articles about N-((tris(4-chlorophenyl)propionyl)glycyl)glycine ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

3,3,3-tris(4-chlorophenyl)propanoyl chloride (2172-49-8) + glycyl glycine ethyl ester hydrochloride (2087-41-4) → N-((tris(4-chlorophenyl)propionyl)glycyl)glycine ethyl ester (556810-25-4)

Guidance literature:

With triethylamine; In dichloromethane; for 18h;

DOI:10.1021/ol0344927

Reference yield:

3,3,3-Tris(4-chlorophenyl)-propionic acid (2168-06-1) → N-((tris(4-chlorophenyl)propionyl)glycyl)glycine ethyl ester (556810-25-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / oxalyl chloride / toluene / 24 h / 20 °C

2: 30 percent / triethylamine / CH₂Cl₂ / 18 h

With oxalyl dichloride; triethylamine; In dichloromethane; toluene;

DOI:10.1021/ol0344927

Reference yield: 97.0%

10-Undecen-1-ol (112-43-6) + N-((tris(4-chlorophenyl)propionyl)glycyl)glycine ethyl ester (556810-25-4) → {2-[3,3,3-tris-(4-chloro-phenyl)-propionylamino]-acetylamino}-acetic acid undec-10-enyl ester (556810-28-7)

Guidance literature:

With 1,3-dichlorotetrabutyldistannoxane; In toluene; for 1h; Heating;

DOI:10.1021/ol0344927

upstream raw materials:

3,3,3-tris(4-chlorophenyl)propanoyl chloride

glycyl glycine ethyl ester hydrochloride

3,3,3-Tris(4-chlorophenyl)-propionic acid

Downstream raw materials:

{2-[3,3,3-tris-(4-chloro-phenyl)-propionylamino]-acetylamino}-acetic acid undec-10-enyl ester

{2-[3,3,3-tris-(4-chloro-phenyl)-propionylamino]-acetylamino}-acetic acid 11-(4-formyl-phenoxy)-undecyl ester