1-Methoxy-4-((1S,2R)-2-methoxy-1-methyl-4-triethylsilanyl-2-trimethylsilanylethynyl-but-3-ynyloxymethyl)-benzene

Base Information

Chemical Name:1-Methoxy-4-((1S,2R)-2-methoxy-1-methyl-4-triethylsilanyl-2-trimethylsilanylethynyl-but-3-ynyloxymethyl)-benzene
CAS No.:886582-81-6
Molecular Formula:C₂₅H₄₀O₃Si₂
Molecular Weight:444.762
Hs Code.:

Synonyms:1-Methoxy-4-((1S,2R)-2-methoxy-1-methyl-4-triethylsilanyl-2-trimethylsilanylethynyl-but-3-ynyloxymethyl)-benzene

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Chemical Property of 1-Methoxy-4-((1S,2R)-2-methoxy-1-methyl-4-triethylsilanyl-2-trimethylsilanylethynyl-but-3-ynyloxymethyl)-benzene

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Technology Process of 1-Methoxy-4-((1S,2R)-2-methoxy-1-methyl-4-triethylsilanyl-2-trimethylsilanylethynyl-but-3-ynyloxymethyl)-benzene

There total 3 articles about 1-Methoxy-4-((1S,2R)-2-methoxy-1-methyl-4-triethylsilanyl-2-trimethylsilanylethynyl-but-3-ynyloxymethyl)-benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 886582-82-7
Triethyl-{(R)-3-methoxy-3-[(S)-1-(4-methoxy-benzyloxy)-ethyl]-penta-1,4-diynyl}-silane

: 75-77-4
chloro-trimethyl-silane

: 886582-81-6
1-Methoxy-4-((1S,2R)-2-methoxy-1-methyl-4-triethylsilanyl-2-trimethylsilanylethynyl-but-3-ynyloxymethyl)-benzene

Guidance literature:: Triethyl-{(R)-3-methoxy-3-[(S)-1-(4-methoxy-benzyloxy)-ethyl]-penta-1,4-diynyl}-silane; With sodium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 0.5h;

chloro-trimethyl-silane; In tetrahydrofuran; at -78 ℃; for 2h;
DOI:10.1039/b601380e

Reference yield:

: 3-[(S)-1-(4-Methoxy-benzyloxy)-ethyl]-1-triethylsilanyl-5-trimethylsilanyl-penta-1,4-diyn-3-ol

: 74-88-4
methyl iodide

: 1-Methoxy-4-((1S,2S)-2-methoxy-1-methyl-4-triethylsilanyl-2-trimethylsilanylethynyl-but-3-ynyloxymethyl)-benzene

: 886582-81-6
1-Methoxy-4-((1S,2R)-2-methoxy-1-methyl-4-triethylsilanyl-2-trimethylsilanylethynyl-but-3-ynyloxymethyl)-benzene

Guidance literature:: 3-[(S)-1-(4-Methoxy-benzyloxy)-ethyl]-1-triethylsilanyl-5-trimethylsilanyl-penta-1,4-diyn-3-ol; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.333333h;

methyl iodide; In tetrahydrofuran; hexane; at -78 - 20 ℃; Title compound not separated from byproducts;
DOI:10.1039/b601380e

Reference yield:

: 1-Methoxy-4-((S)-2-methoxy-1-methyl-4-triethylsilanyl-2-trimethylsilanylethynyl-but-3-ynyloxymethyl)-benzene

: 886582-81-6
1-Methoxy-4-((1S,2R)-2-methoxy-1-methyl-4-triethylsilanyl-2-trimethylsilanylethynyl-but-3-ynyloxymethyl)-benzene

Guidance literature:: Multi-step reaction with 2 steps

1.1: aq. NaOH / methanol; tetrahydrofuran / 1 h / 20 °C

2.1: NaHMDS / tetrahydrofuran / 0.5 h / -78 °C

2.2: 86 percent / tetrahydrofuran / 2 h / -78 °C

With sodium hydroxide; sodium hexamethyldisilazane; In tetrahydrofuran; methanol;
DOI:10.1039/b601380e