(R)-N-[N-(2,2-dimethoxyethyl)glycinyl]-4-methylphenylalanine methyl ester

Base Information

Chemical Name:(R)-N-[N-(2,2-dimethoxyethyl)glycinyl]-4-methylphenylalanine methyl ester
CAS No.:1610691-85-4
Molecular Formula:C₁₇H₂₆N₂O₅
Molecular Weight:338.404
Hs Code.:

Synonyms:(R)-N-[N-(2,2-dimethoxyethyl)glycinyl]-4-methylphenylalanine methyl ester

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Chemical Property of (R)-N-[N-(2,2-dimethoxyethyl)glycinyl]-4-methylphenylalanine methyl ester

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Technology Process of (R)-N-[N-(2,2-dimethoxyethyl)glycinyl]-4-methylphenylalanine methyl ester

There total 3 articles about (R)-N-[N-(2,2-dimethoxyethyl)glycinyl]-4-methylphenylalanine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1610691-81-0
(R)-N-(2-chloroacetyl)-4-methylphenylalanine methyl ester

: 22483-09-6
2,2-dimethoxyethylamine

: 1610691-85-4
(R)-N-[N-(2,2-dimethoxyethyl)glycinyl]-4-methylphenylalanine methyl ester

Guidance literature:: With sodium iodide; In dichloromethane; at 20 ℃; for 48h;
DOI:10.1016/j.tet.2014.04.045

Reference yield:

: (R)-2-amino-3-(4-methylphenyl)propionic acid

: 1610691-85-4
(R)-N-[N-(2,2-dimethoxyethyl)glycinyl]-4-methylphenylalanine methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetyl chloride / 0.25 h / 0 °C

1.2: 38 h / Reflux

2.1: triethylamine / dichloromethane / 1 h / 0 - 20 °C

3.1: sodium iodide / dichloromethane / 48 h / 20 °C

With triethylamine; acetyl chloride; sodium iodide; In dichloromethane;
DOI:10.1016/j.tet.2014.04.045

Reference yield:

: 293742-82-2
(R)-methyl 2-amino-3-(4-tolyl)propanoate hydrochloride

: 1610691-85-4
(R)-N-[N-(2,2-dimethoxyethyl)glycinyl]-4-methylphenylalanine methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 1 h / 0 - 20 °C

2: sodium iodide / dichloromethane / 48 h / 20 °C

With triethylamine; sodium iodide; In dichloromethane;
DOI:10.1016/j.tet.2014.04.045