2,3-dihydro-6-(3-phenoxypropoxy)-5-benzofuranol

Base Information

Chemical Name:2,3-dihydro-6-(3-phenoxypropoxy)-5-benzofuranol
CAS No.:119795-21-0
Molecular Formula:C₁₇H₁₈O₄
Molecular Weight:286.328
Hs Code.:

Synonyms:2,3-dihydro-6-(3-phenoxypropoxy)-5-benzofuranol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2,3-dihydro-6-(3-phenoxypropoxy)-5-benzofuranol

Chemical Property:

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Technology Process of 2,3-dihydro-6-(3-phenoxypropoxy)-5-benzofuranol

There total 8 articles about 2,3-dihydro-6-(3-phenoxypropoxy)-5-benzofuranol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 119795-21-0
2,3-dihydro-6-(3-phenoxypropoxy)-5-benzofuranol

Guidance literature:

Reference yield:

: 128813-68-3
5-Methoxymethoxy-6-(3-phenoxy-propoxy)-2,3-dihydro-benzofuran

: 119795-21-0
2,3-dihydro-6-(3-phenoxypropoxy)-5-benzofuranol

Guidance literature:: With hydrogenchloride; In methanol; at 55 ℃; for 1h; Yield given;
DOI:10.1021/jm00125a014

Reference yield:

: 40492-52-2
2,3-dihydrobenzofuran-5-ol

: 119795-21-0
2,3-dihydro-6-(3-phenoxypropoxy)-5-benzofuranol

Guidance literature:: Multi-step reaction with 8 steps

1: 76.9 percent / Br₂ / CH₂Cl₂ / Ambient temperature

2: 1) NaH / 1) DMF, T < 40 deg C, 2) r.t., 2 h

3: 1) n-BuLi / 1) THF, hexane, -70 deg C, 2 h, 2) a) T < -60 deg C, 1 h, b) to 0 deg C, 40 min

4: 1.42 g / p-nitroperoxybenzoic acid / CH₂Cl₂ / 24 h / Heating

5: 57 percent / KOH / methanol; H₂O / 1 h / Ambient temperature

6: 1) NaH / 1) DMF, 2) DMF, 2 h

7: 1) NaH / 1) DMF, 2) DMF, 60 deg C, 1 h

8: conc. HCl / methanol / 1 h / 55 °C

With hydrogenchloride; potassium hydroxide; n-butyllithium; p-nitroperoxybenzoic acid; bromine; sodium hydride; In methanol; dichloromethane; water;
DOI:10.1021/jm00125a014