1,1-dimethylethyl 4-(5-chloro-3-iodo-2-methylphenyl)piperazine-1-carboxylate

Base Information

Chemical Name:1,1-dimethylethyl 4-(5-chloro-3-iodo-2-methylphenyl)piperazine-1-carboxylate
CAS No.:871339-22-9
Molecular Formula:C₁₆H₂₂ClIN₂O₂
Molecular Weight:436.72
Hs Code.:

Synonyms:1,1-dimethylethyl 4-(5-chloro-3-iodo-2-methylphenyl)piperazine-1-carboxylate

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Chemical Property of 1,1-dimethylethyl 4-(5-chloro-3-iodo-2-methylphenyl)piperazine-1-carboxylate

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Technology Process of 1,1-dimethylethyl 4-(5-chloro-3-iodo-2-methylphenyl)piperazine-1-carboxylate

There total 3 articles about 1,1-dimethylethyl 4-(5-chloro-3-iodo-2-methylphenyl)piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 871339-21-8
1-(5-chloro-3-iodo-2-methylphenyl)piperazine

: 24424-99-5
di-tert-butyl dicarbonate

: 871339-22-9
1,1-dimethylethyl 4-(5-chloro-3-iodo-2-methylphenyl)piperazine-1-carboxylate

Guidance literature:: In tetrahydrofuran; at 20 ℃; for 15h;
DOI:10.1016/j.bmcl.2012.01.105

Reference yield:

: 870606-29-4
5-chloro-3-iodo-2-methylaniline

: 871339-22-9
1,1-dimethylethyl 4-(5-chloro-3-iodo-2-methylphenyl)piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / diethylene glycol dimethyl ether / 24 h / Reflux

2: tetrahydrofuran / 15 h / 20 °C

With potassium carbonate; In tetrahydrofuran; diethylene glycol dimethyl ether;
DOI:10.1016/j.bmcl.2012.01.105

Reference yield:

: 294190-16-2
2-iodo-4-chloro-6-nitrotoluene

: 871339-22-9
1,1-dimethylethyl 4-(5-chloro-3-iodo-2-methylphenyl)piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetic acid; tin(ll) chloride / 1 h / 20 °C

1.2: 0 °C

2.1: potassium carbonate / diethylene glycol dimethyl ether / 24 h / Heating / reflux

3.1: tetrahydrofuran / 15 h / 20 °C

With potassium carbonate; acetic acid; tin(ll) chloride; In tetrahydrofuran; diethylene glycol dimethyl ether;