1,1-dimethylethyl 4-(5-chloro-3-([2-(dimethylamino)ethyl]amino)-2-methylphenyl)-piperazine-1-carboxylate

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Chemical Name:1,1-dimethylethyl 4-(5-chloro-3-([2-(dimethylamino)ethyl]amino)-2-methylphenyl)-piperazine-1-carboxylate
CAS No.:871339-25-2
Molecular Formula:C₂₀H₃₃ClN₄O₂
Molecular Weight:396.961
Hs Code.:

Synonyms:1,1-dimethylethyl 4-(5-chloro-3-([2-(dimethylamino)ethyl]amino)-2-methylphenyl)-piperazine-1-carboxylate

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Chemical Property of 1,1-dimethylethyl 4-(5-chloro-3-([2-(dimethylamino)ethyl]amino)-2-methylphenyl)-piperazine-1-carboxylate

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Technology Process of 1,1-dimethylethyl 4-(5-chloro-3-([2-(dimethylamino)ethyl]amino)-2-methylphenyl)-piperazine-1-carboxylate

There total 4 articles about 1,1-dimethylethyl 4-(5-chloro-3-([2-(dimethylamino)ethyl]amino)-2-methylphenyl)-piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 871339-22-9
1,1-dimethylethyl 4-(5-chloro-3-iodo-2-methylphenyl)piperazine-1-carboxylate

: 108-00-9
N,N-dimethylethylenediamine

: 871339-25-2
1,1-dimethylethyl 4-(5-chloro-3-([2-(dimethylamino)ethyl]amino)-2-methylphenyl)-piperazine-1-carboxylate

Guidance literature:: With sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; for 5h; Heating / reflux;

Reference yield:

: 870606-29-4
5-chloro-3-iodo-2-methylaniline

: 871339-25-2
1,1-dimethylethyl 4-(5-chloro-3-([2-(dimethylamino)ethyl]amino)-2-methylphenyl)-piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / diethylene glycol dimethyl ether / 24 h / Reflux

2: tetrahydrofuran / 15 h / 20 °C

3: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium t-butanolate / 1,4-dioxane / 5 h / Reflux

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium t-butanolate; In tetrahydrofuran; 1,4-dioxane; diethylene glycol dimethyl ether; 3: Buchwald-Hartwig amination;
DOI:10.1016/j.bmcl.2012.01.105

Reference yield:

: 871339-21-8
1-(5-chloro-3-iodo-2-methylphenyl)piperazine

: 871339-25-2
1,1-dimethylethyl 4-(5-chloro-3-([2-(dimethylamino)ethyl]amino)-2-methylphenyl)-piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: tetrahydrofuran / 15 h / 20 °C

2: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium t-butanolate / 1,4-dioxane / 5 h / Reflux

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium t-butanolate; In tetrahydrofuran; 1,4-dioxane; 2: Buchwald-Hartwig amination;
DOI:10.1016/j.bmcl.2012.01.105