N-(tert-butyl)-2-(4-methoxybenzyl)-3-oxo-5-phenyl-2,3-dihydro-1H-benzo[4,5]thieno[2,3-c]azepine-1-carboxamide

Base Information

• Chemical Name: N-(tert-butyl)-2-(4-methoxybenzyl)-3-oxo-5-phenyl-2,3-dihydro-1H-benzo[4,5]thieno[2,3-c]azepine-1-carboxamide
• CAS No.: 1477486-58-0
• Molecular Formula: C₃₁H₃₀N₂O₃S
• Molecular Weight: 510.657

Synonyms:N-(tert-butyl)-2-(4-methoxybenzyl)-3-oxo-5-phenyl-2,3-dihydro-1H-benzo[4,5]thieno[2,3-c]azepine-1-carboxamide

Chemical Property of N-(tert-butyl)-2-(4-methoxybenzyl)-3-oxo-5-phenyl-2,3-dihydro-1H-benzo[4,5]thieno[2,3-c]azepine-1-carboxamide

Chemical Property:

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Technology Process of N-(tert-butyl)-2-(4-methoxybenzyl)-3-oxo-5-phenyl-2,3-dihydro-1H-benzo[4,5]thieno[2,3-c]azepine-1-carboxamide

There total 2 articles about N-(tert-butyl)-2-(4-methoxybenzyl)-3-oxo-5-phenyl-2,3-dihydro-1H-benzo[4,5]thieno[2,3-c]azepine-1-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

N-[1-(benzo[b]thiophen-2-yl)-2-(tert-butylamino)-2-oxoethyl]-N-(4-methoxybenzyl)-3-phenylpropiolamide (1477486-49-9) → N-(tert-butyl)-2-(4-methoxybenzyl)-3-oxo-5-phenyl-2,3-dihydro-1H-benzo[4,5]thieno[2,3-c]azepine-1-carboxamide (1477486-58-0)

Guidance literature:

With (triphenylphosphine)gold(I) chloride; silver trifluoromethanesulfonate; In chloroform; at 50 ℃; for 3h; regioselective reaction; Inert atmosphere;

DOI:10.1055/s-0033-1339474

Reference yield:

benzothiophene-2-carboxaldehyde (3541-37-5) + tert-butylisonitrile (119072-55-8,7188-38-7) + 4-methoxy-benzylamine (2393-23-9) + phenylpropyolic acid (637-44-5) → N-(tert-butyl)-2-(4-methoxybenzyl)-3-oxo-5-phenyl-2,3-dihydro-1H-benzo[4,5]thieno[2,3-c]azepine-1-carboxamide (1477486-58-0)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium sulfate / methanol / 48 h / 50 °C / Inert atmosphere

2: (triphenylphosphine)gold(I) chloride; silver trifluoromethanesulfonate / chloroform / 3 h / 50 °C / Inert atmosphere

With (triphenylphosphine)gold(I) chloride; silver trifluoromethanesulfonate; sodium sulfate; In methanol; chloroform; 1: |Ugi Condensation;

DOI:10.1055/s-0033-1339474

upstream raw materials:

benzothiophene-2-carboxaldehyde

tert-butylisonitrile

4-methoxy-benzylamine

phenylpropyolic acid

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