phenylmethyl (1R)-1-{[4-({[(1,1-dimethylethyl)oxy]carbonyl}amino)-1-piperidinyl]methyl}-3,8-dioxo-1,2,3,4-tetrahydro-5H,8H-2a,5,8a-triazaacenaphthylene-5-carboxylate

Base Information

Chemical Name:phenylmethyl (1R)-1-{[4-({[(1,1-dimethylethyl)oxy]carbonyl}amino)-1-piperidinyl]methyl}-3,8-dioxo-1,2,3,4-tetrahydro-5H,8H-2a,5,8a-triazaacenaphthylene-5-carboxylate
CAS No.:1075237-89-6
Molecular Formula:C₂₈H₃₅N₅O₆
Molecular Weight:537.616
Hs Code.:

phenylmethyl (1R)-1-{[4-({[(1,1-dimethylethyl)oxy]carbonyl}amino)-1-piperidinyl]methyl}-3,8-dioxo-1,2,3,4-tetrahydro-5H,8H-2a,5,8a-triazaacenaphthylene-5-carboxylate

Synonyms:phenylmethyl (1R)-1-{[4-({[(1,1-dimethylethyl)oxy]carbonyl}amino)-1-piperidinyl]methyl}-3,8-dioxo-1,2,3,4-tetrahydro-5H,8H-2a,5,8a-triazaacenaphthylene-5-carboxylate

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Chemical Property of phenylmethyl (1R)-1-{[4-({[(1,1-dimethylethyl)oxy]carbonyl}amino)-1-piperidinyl]methyl}-3,8-dioxo-1,2,3,4-tetrahydro-5H,8H-2a,5,8a-triazaacenaphthylene-5-carboxylate

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Technology Process of phenylmethyl (1R)-1-{[4-({[(1,1-dimethylethyl)oxy]carbonyl}amino)-1-piperidinyl]methyl}-3,8-dioxo-1,2,3,4-tetrahydro-5H,8H-2a,5,8a-triazaacenaphthylene-5-carboxylate

There total 9 articles about phenylmethyl (1R)-1-{[4-({[(1,1-dimethylethyl)oxy]carbonyl}amino)-1-piperidinyl]methyl}-3,8-dioxo-1,2,3,4-tetrahydro-5H,8H-2a,5,8a-triazaacenaphthylene-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.6%

: 1075237-88-5
phenylmethyl (1S)-1-{[(methylsulfonyl)oxy]methyl}-3,8-dioxo-1,2,3,4-tetrahydro-5H,8H-2a,5,8a-triazaacenaphthylene-5-carboxylate

: 73874-95-0
(piperidin-4-yl)carbamic acid tert-butyl ester

: 1075237-89-6
phenylmethyl (1R)-1-{[4-({[(1,1-dimethylethyl)oxy]carbonyl}amino)-1-piperidinyl]methyl}-3,8-dioxo-1,2,3,4-tetrahydro-5H,8H-2a,5,8a-triazaacenaphthylene-5-carboxylate

Guidance literature:: With pyridine; In acetonitrile; at 70 - 80 ℃;

Reference yield:

: 73896-36-3
6-methoxy-3-nitropyridin-2-amine

: 1075237-89-6
phenylmethyl (1R)-1-{[4-({[(1,1-dimethylethyl)oxy]carbonyl}amino)-1-piperidinyl]methyl}-3,8-dioxo-1,2,3,4-tetrahydro-5H,8H-2a,5,8a-triazaacenaphthylene-5-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1.1: hydrogen / palladium on activated charcoal / ethanol / 20 °C / 760.05 Torr

2.1: potassium carbonate / acetonitrile / 20 °C

3.1: sodium hydrogencarbonate / water; ethyl acetate / 0.75 h / 20 °C

4.1: sodium hydride / N,N-dimethyl-formamide / 0.33 h / 0 - 20 °C

4.2: 1 h

5.1: N,N-dimethyl-formamide / 120 - 130 °C

6.1: triethylamine / dichloromethane / 1 h / 0 - 20 °C

7.1: pyridine / acetonitrile / 70 - 80 °C

With pyridine; hydrogen; sodium hydride; sodium hydrogencarbonate; potassium carbonate; triethylamine; palladium on activated charcoal; In ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 38533-61-8
2-chloro-6-methoxy-3-nitropyridine

: 1075237-89-6
phenylmethyl (1R)-1-{[4-({[(1,1-dimethylethyl)oxy]carbonyl}amino)-1-piperidinyl]methyl}-3,8-dioxo-1,2,3,4-tetrahydro-5H,8H-2a,5,8a-triazaacenaphthylene-5-carboxylate

Guidance literature:: Multi-step reaction with 8 steps

1.1: ammonia / methanol / 18 h / 65 °C

2.1: hydrogen / palladium on activated charcoal / ethanol / 20 °C / 760.05 Torr

3.1: potassium carbonate / acetonitrile / 20 °C

4.1: sodium hydrogencarbonate / water; ethyl acetate / 0.75 h / 20 °C

5.1: sodium hydride / N,N-dimethyl-formamide / 0.33 h / 0 - 20 °C

5.2: 1 h

6.1: N,N-dimethyl-formamide / 120 - 130 °C

7.1: triethylamine / dichloromethane / 1 h / 0 - 20 °C

8.1: pyridine / acetonitrile / 70 - 80 °C

With pyridine; ammonia; hydrogen; sodium hydride; sodium hydrogencarbonate; potassium carbonate; triethylamine; palladium on activated charcoal; In methanol; ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;