4-(benzyloxy)-3-{(tert-butyldimethylsilyl)oxy}benzaldehyde

Base Information

• Chemical Name: 4-(benzyloxy)-3-{(tert-butyldimethylsilyl)oxy}benzaldehyde
• CAS No.: 1205539-37-2
• Molecular Formula: C₂₀H₂₆O₃Si
• Molecular Weight: 342.51
• Mol file: 1205539-37-2.mol

Synonyms:4-(benzyloxy)-3-{(tert-butyldimethylsilyl)oxy}benzaldehyde

Chemical Property of 4-(benzyloxy)-3-{(tert-butyldimethylsilyl)oxy}benzaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(benzyloxy)-3-{(tert-butyldimethylsilyl)oxy}benzaldehyde

There total 3 articles about 4-(benzyloxy)-3-{(tert-butyldimethylsilyl)oxy}benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

4-benzyloxy-3-hydroxy-benzaldehyde (4049-39-2) + tert-butyldimethylsilyl chloride (18162-48-6) → 4-(benzyloxy)-3-{(tert-butyldimethylsilyl)oxy}benzaldehyde (1205539-37-2)

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 0 - 20 ℃; for 4h; Inert atmosphere;

DOI:10.1016/j.steroids.2009.06.006

Reference yield:

3,4-dihydroxybenzaldehyde (139-85-5) → 4-(benzyloxy)-3-{(tert-butyldimethylsilyl)oxy}benzaldehyde (1205539-37-2)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

2: triethylamine; dmap / dichloromethane / 20 °C

With dmap; potassium carbonate; triethylamine; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.ejmech.2014.01.016

Reference yield:

benzyl bromide (100-39-0) → 4-(benzyloxy)-3-{(tert-butyldimethylsilyl)oxy}benzaldehyde (1205539-37-2)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

2: triethylamine; dmap / dichloromethane / 20 °C

With dmap; potassium carbonate; triethylamine; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.ejmech.2014.01.016

upstream raw materials:

4-benzyloxy-3-hydroxy-benzaldehyde

tert-butyldimethylsilyl chloride

benzyl bromide

3,4-dihydroxybenzaldehyde

Downstream raw materials:

(4-benzyloxy-3-(tert-butyldimethylsilyloxy)phenyl)methanol

3-(3,4-dihydroxyphenyl)propyl acetate

(E)-3-{4-(benzyloxy)-3-hydroxyphenyl}allyl acetate

(E)-3-[4-(benzyloxy)-3-{(tert-butyldimethylsilyl)oxy}phenyl]allyl acetate