5-(tert-butyldimethyl silyloxy)-1-(4-methoxyphenyl)-1-phenylpentan-2-ol

Base Information

Chemical Name:5-(tert-butyldimethyl silyloxy)-1-(4-methoxyphenyl)-1-phenylpentan-2-ol
CAS No.:503025-53-4
Molecular Formula:C₂₄H₃₆O₃Si
Molecular Weight:400.634
Hs Code.:

Synonyms:5-(tert-butyldimethyl silyloxy)-1-(4-methoxyphenyl)-1-phenylpentan-2-ol

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Chemical Property of 5-(tert-butyldimethyl silyloxy)-1-(4-methoxyphenyl)-1-phenylpentan-2-ol

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Technology Process of 5-(tert-butyldimethyl silyloxy)-1-(4-methoxyphenyl)-1-phenylpentan-2-ol

There total 5 articles about 5-(tert-butyldimethyl silyloxy)-1-(4-methoxyphenyl)-1-phenylpentan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 503025-52-3
tert-butyldimethyl-[3-(3-phenyloxiranyl)propoxy]silane

: 13139-86-1
4-methoxyphenyl magnesium bromide

: 503025-53-4
5-(tert-butyldimethyl silyloxy)-1-(4-methoxyphenyl)-1-phenylpentan-2-ol

Guidance literature:: copper(l) iodide; In tetrahydrofuran; at 20 ℃; for 6h;
DOI:10.1021/ja029139v

Reference yield:

: 591-50-4
iodobenzene

: 503025-53-4
5-(tert-butyldimethyl silyloxy)-1-(4-methoxyphenyl)-1-phenylpentan-2-ol

Guidance literature:: Multi-step reaction with 5 steps

1.1: diisopropylamine / Pd(PPh₃)4 / tetrahydrofuran / 0.33 h / 20 °C

1.2: 99 percent / CuI / tetrahydrofuran / 12 h

2.1: 99 percent / LAH / tetrahydrofuran / 20 h / Heating

3.1: 95 percent / imidazole / dimethylformamide / 0 - 20 °C

4.1: 72 percent / m-CPBA; NaOAc / CH₂Cl₂ / 6 h / 20 °C

5.1: 71 percent / CuI / tetrahydrofuran / 6 h / 20 °C

With 1H-imidazole; lithium aluminium tetrahydride; sodium acetate; diisopropylamine; 3-chloro-benzenecarboperoxoic acid; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja029139v

Reference yield:

: 5390-04-5
pent-1-yn-5-ol

: 503025-53-4
5-(tert-butyldimethyl silyloxy)-1-(4-methoxyphenyl)-1-phenylpentan-2-ol

Guidance literature:: Multi-step reaction with 5 steps

1.1: diisopropylamine / Pd(PPh₃)4 / tetrahydrofuran / 0.33 h / 20 °C

1.2: 99 percent / CuI / tetrahydrofuran / 12 h

2.1: 99 percent / LAH / tetrahydrofuran / 20 h / Heating

3.1: 95 percent / imidazole / dimethylformamide / 0 - 20 °C

4.1: 72 percent / m-CPBA; NaOAc / CH₂Cl₂ / 6 h / 20 °C

5.1: 71 percent / CuI / tetrahydrofuran / 6 h / 20 °C

With 1H-imidazole; lithium aluminium tetrahydride; sodium acetate; diisopropylamine; 3-chloro-benzenecarboperoxoic acid; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja029139v